The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-μm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducib...

Novel amylose ester derivatives were synthesized and their chiral recognition abilities as chiral stationary phases for highperformance liquid chromatography were evaluated. Compared with amylose benzoate derivatives, cinnamate derivatives showed a higher chiral recognition ability and some racemates could be efficiently resolved. The recognition abilities of these derivatives varied significan...

The development of chiral stationary phases (CSPs) for liquid chromatography (LC) revolutionized the enantioseparation and, nowadays, different types of CSPs are commercially available. Polysaccharide-based CSPs are one of the most versatile and widely used for both analytical and preparative applications and they are able to resolve several classes of racemates. Phenylcarbamates of amylose and...

An alternative process for the analysis of mixture library components for their potential as selectors for chiral chromatography is described. The procedure involves the immobilization of each enantiomer of the target racemic analyte to silica gel, followed by incubation of each resulting stationary phase with a mixture library. The adsorbed library components on the two stationary phases are t...

In the present paper the separation of three amino acids applying ligand exchange chromatography in single and dual chiral systems was modeled using the dispersive equilibrium model. The investigated systems consist of a commercially available non chiral column and a commercially available chiral column using a chiral mobile phase. With the experimentally determined model parameters and the mul...

Enantiomer separation represents an important topic especially in pharmaceutical and environmental fields where many drugs and pesticides are racemic compounds. In some cases, only one of the enantiomers has pharmacological or pesticidal activity while the other may exhibit antagonistic activities, unwanted side effects or even toxic effects. Therefore, the development of new enantioseparation ...

In the present study we used chiral high performance liquid chromatography and gas chromatography to determine the stereoisomers of racemic alpha-tocopherol. The Chiralcel OD-H and Silar-100 AT columns were used. Statistical evaluation of the results established the precision of these methods.

Polysaccharides, such as cellulose and amylose, are abundant and optically active carbohydrate-based resources. Their suitably modified derivatives (for example, benzoate and phenylcarbamate derivatives) exhibit excellent resolution abilities for a wide variety of chiral compounds when applied to chiral stationary phases (CSPs) for high-performance liquid chromatography. Despite the established...