We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. With heart rate held constant by electrical stimulation, and with respiration con...

We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. With heart rate held constant by electrical stimulation, and with respiration con...

In this issue, Fletcher et al 1 report that repetitive brief hypoxia applied during a 7-hour period per day for up to 35 days causes diurnal elevation of blood pressure in rats. This significant finding examines the mechanism of chronic, reversible arterial hypertension correlated with sleep apnea syndrome.The hemodynamic pattern of obstructive sleep apnea (OSA) (blood pressure rise at the nadi...

Chemotaxis allows bacteria to detect specific compounds and move accordingly. This pathway involves signal detection by chemoreceptors (MCPs). Attributing a chemoreceptor ligand is difficult because there lot of redundancy in the MCPs that recognize single ligand. We propose methodology define which bind given First, an MCP overproduced increase sensitivity ligand(s) it recognizes, thus promoti...

The intricate structure of prokaryotic and eukaryotic cells depends on the ability to target proteins to specific cellular locations. In most cases, we have a poor understanding of the underlying mechanisms. A typical example is the assembly of bacterial chemoreceptors at cell poles. Here we show that the classical chemoreceptor TlpA of Bacillus subtilis does not localize according to the conse...

Natural isolates of C. elegans differ in their sensitivity to pheromones that inhibit exploratory behavior. Previous studies identified a QTL for pheromone sensitivity that includes alternative alleles of srx-43, a chemoreceptor that inhibits exploration through its activity in ASI sensory neurons. Here we show that the QTL is multigenic and includes alternative alleles of srx-44, a second chem...

Crayfish depend on sensilla, small cuticular structures occurring all over their bodies to acquire information about their outside environment. Sensilla contain sensory neurons that are either mechanoreceptive or chemoreceptive. The tail fan of crayfish houses numerous sensilla that contain mechanoreceptor neurons and their activation by animals approaching from behind elicits a tail-flip escap...

Crayfish depend on sensilla, small cuticular structures occurring all over their bodies to acquire information about their outside environment. Sensilla contain sensory neurons that are either mechanoreceptive or chemoreceptive. The tail fan of crayfish houses numerous sensilla that contain mechanoreceptor neurons and their activation by animals approaching from behind elicits a tail-flip escap...

Amiodarone, lamotrigine, and phenytoin, common antiarrhythmic and antiepileptic drugs, inhibit a persistent sodium current in neurons (I(NaP)). Previous results from our laboratory suggested that I(NaP) is critical for functionality of peripheral chemoreceptors. In this study, we determined the effects of therapeutic levels of amiodarone, lamotrigine, and phenytoin on peripheral chemoreceptor a...

Background Exogenous adenosine has been shown to increase muscle sympathetic nerve activity (MSNA), blood pressure, heart rate, and ventilation in conscious humans, effects attributed to peripheral chemoreceptor activation. Methods and Results To determine whether endogenous adenosine has similar effects and whether they are mediated through chemoreceptor activation, we examined the effects of ...