Exploration of the chemical patent space is essential for early-stage medicinal chemistry activities. The BioCreative CHEMDNER-patents task focuses on the recognition of chemical compounds in patents. This includes recognition of chemical named entities in patents (CEMP), classification of chemical-related patent titles and abstracts (CPD), and recognition of genes and proteins in patent abstra...

Aims: Post Traumatic Stress Disorder is a problem which affects both victims’ and their families’ quality of life and experiencing Injury by each family member can affect other members of the family. This study was performed to evaluate the symptoms of secondary Post Traumatic Stress Disorder among chemical warfare victims’ children. Methods: This descriptive-analytical cross-sectional study wa...

BACKGROUND It is well known that inhalation of chemical warfare, mostly sulfur mustard, causes injury of the respiratory system. Chronic obstructive pulmonary disease is a common disease among these patients. Health-related quality of life is a common feature of studies in chronic obstructive pulmonary disease. The objective of our study was to assess the quality of life in these patients. ME...

Reddit.com is a website that is primarily organized by communities called subreddits, where users can post comments to. As subreddits can have very different cultures, we aim to classify comments by subreddit as a means of sentiment analysis. We use a publicly available reddit comment dataset over the year of 2016 and perform a classification on a selection of 20 subreddits among the top 50 by ...

Tablets are one of the most popular and preferred solid dosage forms because they can be accurately dosed, easily manufactured and packaged on a large scale, have good physical and chemical stability, and can contribute to good patient compliance given their ease of administration. The ability to match doses to patients depends on the availability of multiple dose sizes and adequate dose-respon...

INTRODUCTION Metastasis is a crucial aspect of cancer. Macrophage stimulating protein (MSP) is a single chain protein and can be cleaved by serum proteases. MSP has several roles in metastasis. In this in silico study, MSP as a metastatic agent was considered as a drug target. METHODS Crystallographic structure of MSP was retrieved from protein data bank. To find a chemical inhibitor of MSP, ...

Cancer is the leading cause of death worldwide. Screening anticancer candidates from tens of millions of chemical compounds is expensive and time-consuming. A rapid and user-friendly web server, known as CDRUG, is described here to predict the anticancer activity of chemical compounds. In CDRUG, a hybrid score was developed to measure the similarity of different compounds. The performance analy...

Biomedical literature is an important source of information for chemical compounds. However, different representations and nomenclatures for chemical entities exist, which makes the reference of chemical entities ambiguous. Many systems already exist for gene and protein entity recognition, however very few exist for chemical entities. The main reason for this is the lack of corpus to train nam...

As a continuation of our efforts in developing new antimycobacterial agents, a series of new 1,3-thiazolidine-2-thione derivatives were synthesized. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. The analysis of theoretical toxicity risks,drug-likeness and drug-score for these series using Osiris program showed acceptable results.