Gene therapy is in its development stage as a novel method for cancer treatment. Liposomes look promising as gene delivery vectors; however, investigations have shown that these vesicles are not doing well in some cases. It was decided here to investigate the possibility of augmentation of liposomal gene delivery by chemical penetration enhancers. Cationic liposome containing antisense oligonuc...

A dizzying array of chemical compounds is used in modern food. Artificially manufactured dyes, preservatives, flavors, texture enhancers, and fats enhance the way food looks, tastes, and feels. Considerable debate has raged over the long-term safety of chemical food additives, which are regulated by the Food and Drug Administration (FDA) in the United States. The FDA allows the addition of non-...

Most delivery systems for small interfering RNA therapeutics depend on endocytosis and release from endo-lysosomal compartments. One approach to improve delivery is to identify small molecules enhancing these steps. It is unclear to what extent such enhancers can be universally applied to different delivery systems and cell types. Here, we performed a compound library screen on two well-establi...

José Juan Escobar-Chávez1,*, Isabel Marlen Rodríguez-Cruz2 and Clara Luisa Domínguez-Delgado2 1Unidad de Investigación Multidisciplinaria, Laboratorio 12: Materiales Nanoestructurados y Sistemas Transdérmicos, Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli, Estado de México, 2Departamen...

Transdermal drug delivery systems (TDDS) are used to deliver the drug(s) or therapeutically active substances through topical route primarily skin. Relatively very small numbers of drugs administered transdermally because in many cases physical properties drugs, including polarity and molecular size, have limited its capacity particular dug transdermally. Now a day’s transdermal techniques vari...

Neural crest cells generate a range of cells and tissues in the vertebrate head and trunk, including peripheral neurons, pigment cells, and cartilage. Neural crest cells arise from the edges of the nascent central nervous system, a domain called the neural plate border (NPB). NPB induction is known to involve the BMP, Wnt and FGF signaling pathways. However, little is known about how these sign...

      Lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. It has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. To overcome the poor bioavailability of the drug, transdermal patches have been prepared. The present study also aims at optimizati...

The stratum corneum is a major barrier of drug penetration across the skin in transdermal delivery. For effective transdermal drug delivery, skin penetration enhancers are used to overcome this barrier. In the past decades, a number of research studies were conducted to understand the mechanisms of skin penetration enhancers and to develop a structure enhancement relationship. Such understandin...

despite extensive evidence for cognitive deficits associated with drug use and multiple publications supporting the efficacy of cognitive rehabilitation treatment (crt) services for drug addictions, there are a few well-structured tools and organized programs to improve cognitive abilities in substance users. most published studies on cognitive rehabilitation for drug dependent patients used re...