نتایج جستجو برای: checks and balances
تعداد نتایج: 16828185 فیلتر نتایج به سال:
Age-associated changes in the immune system including alterations in surface protein expression are thought to contribute to an increased susceptibility for autoimmune diseases. The balance between the expression of coinhibitory and costimulatory surface protein molecules, also known as immune checkpoint molecules, is crucial in fine-tuning the immune response and preventing autoimmunity. The a...
The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5. However, the mechanisms for coordination between Fe-S cluster assembly, FBXL5, and IRP1/IRP2 activity are poorly defined. A new study reveals that FBXL5 plays a critical role in limiting IRP1 and IRP2 overaccumulation when cyto...
the administrative system is a means of achieving the goals of political, economic, social and cultural systems of any society. it seems the nature and content of administrative management system affected by the construction and nature of governing system in every society. thus, there is a proactive relationship between these systems. therefore competency-based administrative system is equivale...
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