It seems you?re ready to sharpen your chancroid (starts with a "sh" sound) knowledge! On to it then: Chancroid is a bacterial infection transmitted through contact with sores on an infected individual?s skin. The bacteria, Haemophilus ducreyi, can lead to painful, open sores and swollen lymph nodes, usually in the groin area. It's relatively rare in the United States (including in infants and c...

Haemophilus ducreyi, the etiologic agent of chancroid, has an obligate requirement for heme. Heme is acquired by H. ducreyi from its human host via TonB-dependent transporters expressed at its bacterial surface. Of 3 TonB-dependent transporters encoded in the genome of H. ducreyi, only the hemoglobin receptor, HgbA, is required to establish infection during the early stages of the experimental ...

Background The identification of the causative agent of chancroid, Haemophilus ducreyi, was first reported in 1889 by August Ducrey, as a short streptobacillary rod with rounded ends, following experiments in which he autoinoculated patients’ forearms with pus from their genital ulcers. Bezancon et al subsequently inoculated the forearms of human volunteers with culture purified organisms and p...

One hundred and thirty six patients with chancroid were treated with four different treatment regimens; (A) Sulphaphenazole 1 g 12 hourly by mouth x 10 days (B) Inj streptomycin 1 g intramuscularly daily with sulphaphenazole 1 g 12 hourly orally x 10 days; (C) trimethoprim 200 mg 12 hourly by mouth x 7-10 days, and (D) erythromycin 500 mg 6 hourly orally x 7-10 days. Cure rates of 9% with sulph...

It seems you?re ready to sharpen your chancroid (starts with a "sh" sound) knowledge! On to it then: Chancroid is a bacterial infection transmitted through contact with sores on an infected individual?s skin. The bacteria, Haemophilus ducreyi, can lead to painful, open sores and swollen lymph nodes, usually in the groin area. It's relatively rare in the United States (including in infants and c...

The emergence of Haemophilus ducreyi resistant to multiple antibiotics has limited the effectiveness of sulfonamides and tetracycline for the therapy of chancroid. A randomized, double-blind study compared 10-day courses of erythromycin base (500 mg) and rosaramicin (250 mg) each given four times daily for the treatment of men with chancroid in Nairobi, Kenya. Of 99 evaluable patients, 84 were ...

We aimed to determine if the clinical and histological features of chancroid are altered by HIV infection. Male patients presenting to the Nairobi special treatment clinic with a clinical diagnosis of chancroid were eligible for the study. A detailed history, physical examination, swabs for Haemophilus ducreyi culture and blood for HIV serology, syphilis serology and CD4 counts were obtained fr...

It seems you?re ready to sharpen your chancroid (starts with a "sh" sound) knowledge! On to it then: Chancroid is a bacterial infection transmitted through contact with sores on an infected individual?s skin. The bacteria, Haemophilus ducreyi, can lead to painful, open sores and swollen lymph nodes, usually in the groin area. It's relatively rare in the United States (including in infants and c...

It seems you?re ready to sharpen your chancroid (starts with a "sh" sound) knowledge! On to it then: Chancroid is a bacterial infection transmitted through contact with sores on an infected individual?s skin. The bacteria, Haemophilus ducreyi, can lead to painful, open sores and swollen lymph nodes, usually in the groin area. It's relatively rare in the United States (including in infants and c...