BACKGROUND Frequent beta-catenin mutations have been detected in juvenile angiofibromas, but the tumor pathogenesis remains unknown. METHODS Metaphase-comparative genomic hybridization (CGH) was used to identify chromosomal aberrations in 29 tumor specimens. Two tumors were investigated using genome DNA microarrays. RESULTS Three hundred eleven chromosomal gains and losses were detected by ...

before and after birth, mental retardation, developmental delay, cardiac anomalies, minor anomalies of genitalia in boys, abnormal skin pigmentation and dysmorphic features. Array comparative genomic hybridization (CGH) analysis has recently become a widely used method for detecting DNA copy number changes, in place of traditional karyotype analysis. In particular, an international consensus st...

Cytogenetic and molecular genetic studies of glioblastoma multiforme (GBM) have shown that the most frequent alterations are gains of chromosome 7, losses of 9p loci and chromosome 10, and gene amplification, primarily of the epidermal growth factor receptor (EGFR) gene. Although this profile is potentially useful in distinguishing GBM from other tumor types, the techniques used tend to be labo...

Microarray comparative genomic hybridization (CGH) has proven to be a specific, sensitive, and rapid technique, with considerable advantages compared to other methods used for analysis of DNA copy number changes. Array CGH allows for the mapping of genomic copy number alterations at the sub-microspecific level, thereby directly linking disease phenotypes to gene dosage alterations. The whole hu...

In Caenorhabditis elegans, lack of the conserved germline RNA helicase CGH-1 causes infertility and excessive levels of physiological germline apoptosis, a process that normally claims about half of all developing oocytes. In yeast the CGH-1 ortholog is a key component of degradative "processing (P) bodies," which may share some properties with germline protein-RNA complexes such as P granules....

Computer -generated holograms (CGHs) are used in a number of important optical technology application areas such as holographic optical elements, optical processing and computing, optical testing, image and information display, beam forming, and beam scanning. Many different CGH fabrication devices (e.g., laser beam scanners, electron beam writers) and facilities have been developed and are in ...

A circular null computer-generated hologram (CGH) was used to test a highly paraboloidal mirror (diameter, 90 mm; f number, 0.76). To verify the null CGH test a classic autocollimation test with a flat mirror was performed. Comparing the results, we show that the results of the null CGH test show good agreement with results of the autocollimation test.

To ensure the performance of optical system, machining accuracy lens with long focal lengths is required to image quality. A new method for transmission wavefront power spectral density (PSD) in mid-frequency domain measurement using binary phase computer-generated hologram (CGH) presented. This technique widely applicable and particularly useful measuring large-size lenses lengths. comparison ...

A color-tunable novel-look-up-table (CT-NLUT) for fast one-step calculation of full-color computer-generated holograms is proposed. The proposed method is composed of four principal fringe patterns (PFPs) such as a baseline, a depth-compensating and two color-compensating PFPs. CGH patterns for one color are calculated by combined use of baseline-PFP and depth-compensating-PFP and from them, th...