This work describes the direct hyphenation of cation exchange chromatography (CEX) with a compact, easy-to-use benchtop Time Flight mass spectrometer (ToF/MS) for analytical characterization monoclonal antibodies (mAbs). For this purpose, wide range commercial mAb products (including expired samples and biosimilars) were selected to draw reliable conclusions. From chromatographic point view, va...

BACKGROUND The mini-Clinical Evaluation Exercise (mini-CEX) is used to assess medical students' clinical skills during medicine clerkships. PURPOSE To evaluate reliability, feasibility, and user satisfaction of a paper vs PDA-based mini-CEX in a third-year medicine clerkship. METHODS The mini-CEX was reformatted as a PDA-based rating form for a medicine clerkship over 1 year. Faculty and re...

1 This study examined whether the exercise-increased extracellular heat shock protein 72 2 (eHsp72) level in rat was associated with body temperature elevation during exercise. In all, 3 26 female Sprague-Dawley rats (3 months old) were assigned randomly to control (CON, n = 4 8), exercise under warm temperature (WEx, n = 9), or exercise under cold temperature (CEx, 5 n = 9). The WEx and CEx we...

Resumo Este estudo buscou explorar e comparar a percepção dos riscos à saúde física os comportamentos de do sexo casual entre universitárias com (CEX) sem experiência (SEX) casual. Participaram 1.133 brasileiras (média idade igual 21,05 anos, DP = 2,05), maioria nascidas residentes na região Sul país, que responderam um questionário on-line questões sobre físicos, saúde, comportamento histórico...

Valid, direct observation of medical student competency in clinical settings remains challenging and limits the opportunity to promote performance-based student advancement. The rationale for direct observation is to ascertain that students have acquired the core clinical competencies needed to care for patients. Too often student observation results in highly variable evaluations which are ske...

Background: The practice of exercise in short bouts repeated throughout the day may be an alternative strategy to lift people out of physical inactivity. Objective: to evaluate if accumulated exercise, as occurs in continuous exercise training, improve endothelial function in rat aorta. Methods: Wistar male rats were divided into three groups: continuous exercise (CEx, 1 hour on the treadmi...

BACKGROUND AND OBJECTIVES Mini Clinical Evaluation eXercise (mini-CEX) involves observation of routine clinical encounters, initially developed to assess clinical competencies of postgraduate doctors. This study aimed to measure its inter-rater reliability in assessment of medical students in general practice settings. METHODS General practitioners (GPs) supervising medical students were invi...

Despite the growing adoption of decentralized exchanges, not much is yet known about their market quality. To shed light on this issue, we compare blockchain-based venues (DEX) to centralized crypto exchanges (CEX) by assessing two key aspects quality: price efficiency and liquidity. Using a novel comprehensive data set, find that overall CEX provide better quality but DEX become competitive fo...

Abstract Background The traditional curriculum for medical students in Japan does not include sufficient opportunities to develop their skills musculoskeletal (MSK) examination and clinical reasoning diagnosis. Therefore, an effective programme is required help residents improve MSK. This paper aims assess the of who have participated a peer role-playing simulation using mini evaluation exercis...