نتایج جستجو برای: cervical cancer cc
تعداد نتایج: 995941 فیلتر نتایج به سال:
Cervical cancer (CC) still has a high incidence despite screening programmes and access to human papillomavirus (HPV) vaccination, with poor prognosis in the advanced setting. Most cases of cervical carcinoma are related HPV infection. The pathogen-induced nature disease, involvement genes regulating immune response grade infiltration provide rationale evaluate anti-programmed death-(ligand)1 (...
OBJECTIVE Cervical cancer is an important cause of mortality among women in developing countries, especially in the Latin America and Caribbean (LAC) region. Infection with high-risk (HR) human papillomavirus (HPV) has been identified as the primary cause of cervical cancer. The aim of this study was to determine the frequency of HR-HPV genotypes in low-grade and high-grade squamous intraepithe...
Dysregulated expression of microRNAs (miRNAs) has been observed in numerous types of human cancer, including cervical cancer (CC). The present study aimed to elucidate the expression and roles of miR‑181 in cervical cancer tissues and cells. HeLa cells with a stable overexpression of miR‑181 were generated and injected subcutaneously into the front legs of nude mice. Functional assays revealed ...
Different rate of development of productive infections (as low grade cervical intraepithelial neoplasias), or high grade lesions and cervical malignant tumors associated with infections of the Transformation zone (TZ) by High-Risk Human Papillomavirus (HR-HPV), could suggest that different epithelial host target cells could exist. If there is more than one target cell, their differential infect...
Cervical Cancer (CC) remains one of the leading causes death among reproductive-age females globally. Screening and vaccination CC are still low females, hence increase in toll from disease. This study investigated factors influencing uptake cervical cancer screening female workers at selected hospitals Abuja, Nigeria. Using a descriptive quantitative design, self-administered questionnaires we...
BACKGROUND Numerous epidemiological studies have been conducted to evaluate the association between variants of the DNA repair gene XRCC3 and cancer risk. Here we focused on one XRCC3 polymorphism and development of cervical cancer, performing a meta-analysis. METHODS The pooled association between the XRCC3 Thr241Met polymorphism and cervical cancer risk was assessed by odds ratios (ORs) and...
BACKGROUND Human papillomavirus (HPV) infection is considered the major cause of cervical cancer (CC), but a number of infected women do not develop invasive lesions, suggesting the role of genetic susceptibility and environmental co-factors for cancer outbreak. Glutathione S- transferases (GSTs) are multifunctional enzymes that play a key role in the detoxification of varieties of both endogen...
Cervical cancer (CC) remains a public health concern in Cote d’Ivoire. The national policy for the prevention of cervical has been introduced more than 10 years ago, while coverage target population is still suboptimal. We aimed at describing barriers to screening among women Abidjan. A mixed method study was completed from February August 2016. Stakeholders were interviewed according the...
BACKGROUND A number of studies have explored the association between methyl enetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia (CIN). However, results remained controversial. To address this gap, we decided to conduct a meta-analysis of all available published studies. METHODS Electronic literature searches of ...
PURPOSE Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Th1 responses and thus participates in the carcinogenesis of human papillomavirus-related cervical cancer. We hypothesized that potentially functional polymorphisms in IL12A and IL12B may individually and jointly contribute to cervical cancer risk. EXPERIMENTAL DESIGN We genotyped IL12A rs568408 [3'...
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