نتایج جستجو برای: cerulein

تعداد نتایج: 349  

2014
Sarah Müller Burkhard Krüger Falko Lange Cristin N. Bock Horst Nizze Änne Glass Saleh M. Ibrahim Robert Jaster

A polymorphism in the ATP synthase 8 (ATP8) gene of the murine mitochondrial genome, G-to-T transversion at position 7778, has been suggested to increase susceptibility to multiple autoimmune diseases, including autoimmune pancreatitis (AIP). The polymorphism also induces mitochondrial reactive oxygen species generation, secretory dysfunction and β-cell mass adaptation. Here, we have used two c...

Journal: :Clinical hemorheology and microcirculation 2012
Robert Kotan Norbert Nemeth Ferenc Kiss Janos Posan Kornel Miszti-Blasius Laszlo Toth Istvan Furka Iren Miko Peter Sapy Zsolt Szentkereszty

Although microcirculatory disturbances play pivotal role in the pathomechanism of acute pancreatitis (AP), very few papers can be found which had been tested any of hemorheological parameters. The aim of our study was to analyze the hemorheological changes in cerulein-induced experimental acute pancreatitis in rat in two doses (5 and 10 μg/kg, s.c.). Male and female rats were subjected to Contr...

Journal: :Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 2011
Nuriye Esen Bulut Erkan Özkan Osman Ekinci Ender Dulundu Ümit Topaloğlu Ahmet Özer Şehirli Feriha Ercan Göksel Şener

BACKGROUND The present study aimed to determine the effects of alpha lipoic acid (ALA) on blood and tissue biochemical parameters, as well as tissue histopathology, in an experimental rat model of cerulein-induced acute pancreatitis (AP). METHODS Three groups consisting of eight rats each were used, as follows: Group 1, controls; Group 2, cerulein-induced pancreatitis group treated with salin...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2010
Barbara Ulmasov Zekuan Xu Vanita Talkad Kiyoko Oshima Brent A Neuschwander-Tetri

The intraorgan renin-angiotensin system (RAS) plays an important role in the pathophysiology of a variety of diseases and has been implicated in fibrogenesis. The role of RAS in the development of chronic pancreatitis is not well established. The blockade of RAS in rat models with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor 1 (AT1) blockers (ARBs) mostly have reduced...

Journal: :Clinics 2007
Wellington Andraus José Jukemura Fernando Dutra Etelvino Bechara José E M Cunha Katia R M Leite Marcel Cerqueira César Machado

BACKGROUND Hypothermia is a frequent event in severe acute pancreatitis (AP) and its real effects on the normal pancreas have not been well demonstrated. Moreover, neither have its effects on the outcome of acute pancreatitis been fully investigated. One hypothesis is that oxidative stress may be implicated in lesions caused or treated by hypothermia. AIM OF THE STUDY To investigate the effec...

Journal: :Gut and liver 2008
Hyeyoung Kim

Cerulein pancreatitis is similar to human edematous pancreatitis, manifesting with dysregulation of digestive enzyme production and cytoplasmic vacuolization, the death of acinar cells, edema formation, and infiltration of inflammatory cells into the pancreas. Reactive oxygen species are involved in nuclear factor-kappaB activation, cytokine expression, apoptosis and pathogenesis of pancreatiti...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
L Gómez-Cambronero B Camps J G de La Asunción M Cerdá A Pellín F V Pallardó J Calvete J H Sweiry G E Mann J Viña J Sastre

Reactive oxygen radicals, nitric oxide, and cytokines have been implicated in the initiation of pancreatic tissue damage and impairment of the pancreatic microcirculation in acute pancreatitis. Pentoxifylline is a methylxanthine derivative with rheologic and marked anti-inflammatory properties and inhibits the production of proinflammatory cytokines. We have examined whether pentoxifylline amel...

Journal: :Journal of pharmacological sciences 2007
Kentaro Hamada Masanori Yoshida Hiroyuki Isayama Yoshiki Yagi Shuichi Kanazashi Yasunari Kashihara Koji Takeuchi Isamu Yamaguchi

The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-CPA, a 5-HT depletor, it was exaggerated by the preferential 5-HT2A a...

2012
Dechun Feng Ogyi Park Svetlana Radaeva Hua Wang Shi Yin Xiaoni Kong Mingquan Zheng Sam Zakhari Jay K. Kolls Bin Gao

Pancreatitis occurs when digestive enzymes are activated in the pancreas. Severe pancreatitis has a 10-30% mortality rate. No specific treatments for pancreatitis exist now. Here, we discovered that interleukin-22 (IL-22) may have therapeutic potential in treating acute and chronic pancreatitis. Wild-type and IL-22 knockout mice were equally susceptible to cerulein-induced acute and chronic pan...

Journal: :Journal of the South African Veterinary Association 2007
K W Romański

Cholecystokinin exerts a composite influence on gastrointestinal motility but little is known about its effect on small-intestinal slow waves. Thus, six rams were implanted with four bipolar serosal electrodes onto the duodeno-jejunal wall. In the course of chronic experiments the myoelectric activity was continuously recorded in the non-fasted animals. After recording of the full normal migrat...

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