in pregnant mothers maternal diabetes happens when the pancreas cannot produce enough insulin, soblood glucose increases in the mother and then in the fetus, resulting in several injuries in neonates. thisstudy was conducted to evaluate the effects of maternal diabetes on fetal cerebrum. sixteen adult female rats were divided in two equal groups. diabetes was induced in one group by alloxan. bo...

we report a patient diagnosed with whipple's disease (wd) who presented only with neurological symptoms. neuroimaging (mri) showed lesions with marked mass effect similar to infiltrative tumors, which were hypersignal on long tr and hyposignal on short tr images, located in several areas of the brain. in serial controls, lesions resolved with gliosis and atrophic changes as well as migration of...

Introduction Current numerical head models that are used to predict traumatic brain injury resulting from accidents have no detailed geometry of the cerebrum (Figure 1). Therefore, these head models have no direct link to tissue-based injury criteria. To investigate the influences of the heterogeneities of the cerebral cortex, a model has been developed with a detailed geometry of a small secti...

We describe a case of choroid plexus carcinoma arising in the cerebrum of a 7-week-old male Sprague-Dawley rat. The tumor mass occupied the right lateral ventricle of the cerebrum. Histological analyses revealed that the epithelial tumor cells had proliferated in tubular, cribriform, papillary and solid growth patterns in the vicinity of the choroid plexus, with slight invasion into the cerebru...

©2000 Dana Press The Dana Foundation www.dana.org About the Author: Martin H. Teicher, M.D., Ph.D., directs the Developmental Biopsychiatry Research Program and is chief, Laboratory of Developmental Psychopharmacology, at McLean Hospital. His recent studies have been of the neurobiological effects of childhood mistreatment and the neurobiology of attention deficit/hyperactivity disorder. A R T ...

Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Legumain activity has been detected in various mouse tissues including the kidney, spleen and epididymis. Legumain is overexpressed in the majority of human solid tumors and transcription of the legumain gene is regulated by the p53 tumor suppressor in HCT116 cells. The legumain activity is also increased under acid conditions in Alzheime...