نتایج جستجو برای: cerebral malaria
تعداد نتایج: 226753 فیلتر نتایج به سال:
BACKGROUND Molecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria-specifically, cerebral malaria-are still unclear. Transforming growth factor beta (TGF-beta) family members are important regulators of inflammation that influence malaria pathogenesis. The soluble form of the auxiliary receptor endoglin (sEng) may play a role in malaria pathogenesis. METHODS ...
Malaria is a formidable global parasitic infection that presents a major health challenge in tropical countries especially among children. A total of 130 children (65 males and 65 females) with cerebral malaria and the same number and ratio for healthy children were considered as control; all aged 1-9 years. Standard haematological method was used to determine the Packed cell volume, platelet a...
Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review focuses on the utility of PPARγ agonists as an adjunctive therapy for the treatment of cerebral ...
Cerebral malaria is a diffuse encephalopathy associated with seizures and status epilepticus which can occur in up to one-third of patients with severe malaria, particularly that caused by Plasmodium falciparum. In this article, we report three cases of Plasmodium vivax malaria (all adult male patients) complicated by seizures and symptoms of diffuse meningoencephalitis. Two patients had predom...
BACKGROUND Severe malaria may influence inner ear function, although this possibility has not been examined prospectively. In a retrospective analysis, hearing impairment was found in 9 of 23 patients with cerebral malaria. An objective method to quickly evaluate the function of the inner ear are the otoacoustic emissions. Negative transient otoacoustic emissions are associated with a threshold...
Malaria is a major health problem in tropical countries. Among its complications, cerebral malaria is the most devastating and can present as hemiplegia, convulsions, disorientation, delirium, coma and finally death1,2. Rare complications of cerebral malaria such as spontaneous subdural empyema and subarachnoid hemorrhage has also been reported in literature1,3,4. We report development of spont...
Malaria is one of the most serious of all tropical parasitic diseases: a severe and life-threatening form of which in humans is cerebral malaria, a complication that can occur in malaria caused by Plasmodium falciparum. This grave complication involves malarial infection of the red blood cells that accumulate within the very small capillaries that fl ow through the tissues of the brain. Even wh...
2482 INSIGHTS | The Journal of Experimental Medicine Malaria is caused by Plasmodium parasites and is commonly thought of as a disease resulting from the cyclic infection and destruction of red blood cells. However, a subset of infected individuals will develop “cerebral malaria”—a pathogenic neuroinflammation, presumably caused by parasitized red blood cells sequestering in the brain. Those af...
2482 INSIGHTS | The Journal of Experimental Medicine Malaria is caused by Plasmodium parasites and is commonly thought of as a disease resulting from the cyclic infection and destruction of red blood cells. However, a subset of infected individuals will develop “cerebral malaria”—a pathogenic neuroinflammation, presumably caused by parasitized red blood cells sequestering in the brain. Those af...
Plasma levels of interleukin (IL)-6, soluble IL-6 receptor, soluble gp130, leukemia inhibitory factor (LIF), and ciliary neutrophic factor (CNTF) were analyzed in 32 patients with severe malaria. Ten had renal failure, 8 had cerebral malaria, and 14 had other causes of severity. Before treatment, the IL-6 and soluble IL-6 receptor plasma levels were significantly higher in persons with cerebral...
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