Emerging line research showed that silk nanoparticles (NPs) have toxicity on the fibroblastand Huvec cells without any toxicity recognized mechanisms. Recently, it suggested peripheralarterial disease confounds almost eight million Americans. Also, due to the main effect offibroblast in a production of extracellular matrix (ECM), adhesive molecules, glycoproteinsand various cytokines, it decide...

By discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. Reactive metabolites contributing to cytotoxicity can also be identified. In this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...

Objective(s):  Protective effects of different extracts and essential oil from Pimpinella anisum           L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in...

Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory, cognition, learning, as well as cellular metabolism. However, ingestion of foodstuffs rich in monosodium glutamate can result in the outbreak of severa...

Emerging line research showed that silk nanoparticles (NPs) have toxicity on the fibroblastand Huvec cells without any toxicity recognized mechanisms. Recently, it suggested peripheralarterial disease confounds almost eight million Americans. Also, due to the main effect offibroblast in a production of extracellular matrix (ECM), adhesive molecules, glycoproteinsand various cytokines, it decide...