Peripheral T-cell lymphoma, not otherwise specified is a heterogeneous group of aggressive neoplasms with indistinct borders. By gene expression profiling we previously reported unsupervised clusters of peripheral T-cell lymphomas, not otherwise specified correlating with CD30 expression. In this work we extended the analysis of peripheral T-cell lymphoma molecular profiles to prototypical CD30...

Primary cutaneous B-cell lymphomas are B-cell non-Hodgkin's lymphomas that arise in the skin. The major subtypes discerned are follicle center cell lymphomas, immunocytomas (marginal zone B-cell lymphomas), and large B-cell lymphomas of the leg. In this study, we analyzed the variable heavy chain (VH) genes of 7 of these lymphomas, ie, 4 follicle center cell lymphomas (diffuse large-cell lympho...

Cutaneous lymphomas comprise a spectrum of diseases characterized by infiltration of the skin by malignant lymphocytes. The clinical manifestations of cutaneous lymphomas vary, and they can mimic benign dermatoses, as well as nodal or visceral malignancies with cutaneous spread. Cutaneous lymphomas are divided into T-cell lymphomas and B-cell lymphomas. Cutaneous T-cell lymphomas include mycosi...

Follicular helper T-cell (TFH) lymphomas comprise a unique group of that represent neoplastic proliferations follicular T-cells and share genetic, immunophenotypic, morphologic, clinical features. Angioimmunoblastic lymphoma (AITL) is the prototypical TFH lymphoma; in addition, 2017 revised World Health Organization (WHO) 4th edition recognizes two other subtypes: (FTCL) nodal peripheral with T...

In the present study, we described cyto-histopathological features and immunophenotyping of the large B-cell lymphoma in an 8-year-old mixed breed dog with applying the World Health Organization (WHO) system of classification of canine lymphomas. In fine-needle aspiration (FNA), lymph nodes were involved by neoplastic cells of intermediate to large size with deep blue cytoplasm; consist of cent...

The Pax5 gene encodes the B-cell-specific activator protein which is a key regulator in development and differentiation of B-cell. We studied the expression of Pax5 in hematologic malignancies to evaluate the diagnostic utility as a B cell marker. Materials included 70 B cell lymphomas, 26 T cell lymphomas, 53 acute leukemias, and 6 multiple myelomas (MMs). Representative areas from the paraffi...

Introduction: Mature T and NK-cell lymphomas represent a heterogeneous group of lymphoid disorders (29 subtypes according to the 2016 WHO classification) arising from mature cells post-thymic origin with different morphological characteristics, phenotypes, clinical presentation. Following success Cell Project (TCP), which allowed analysis more than 1,500 cases peripheral T-Cell (PTCLs) collecte...

Triple hit lymphomas (THL) comprise a rare, heterogenous group of and like many B-cell lymphomas, chromosomal translocations are biologic diagnostic hallmarks disease. Traditionally referred to as subset double (DHL) in literature, THLs characteristically involve rearrangements c-MYC, BCL-2, BCL-6 oncogenes. Many case series high-grade lymphoma, especially MYC/BCL2 have been described the but r...