Myocardial infarction (MI) activates the epicardium to form epicardial stromal cells (EpiSC) that reside in hypoxic microenvironment. Paracrine factors secreted by EpiSC were shown modulate injury response of post-MI heart and improve cardiac function. We have previously reported expression angiogenic cytokines vascular endothelial growth factor A (VEGFA) IL-6 is strongly upregulated adenosine ...

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great promise against multiple cancers, it been largely ineffective in PDAC. This lack of part attributed its extensive, fibroinflammatory stroma and hypoxic microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant s...

Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However, the exact mechanisms underlying this process are not well understood. Moreover, according to the cell lines, hypoxia differently influences cell death. The study of the effects of hypoxia on the apoptosis induced by 5 chemotherapeutic drugs in 7 cancer cell types showed that hypoxia generally inhibited t...

Hypoxia is a common factor of numerous ocular diseases that lead to dysfunctions and loss retinal ganglion cells (RGCs) with subsequent vision loss. High-voltage-activated calcium channels are the main source entry into neurons. Their activity plays central role in different signaling processes health diseases, such as enzyme activation, gene transcription, synaptic transmission, or onset cell ...

In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells a stem-like phenotype. this paper, we develop investigate phenotype-structured model solid tumour growth in which are structured by stemness level, varies continuously between terminally differentiated behaviours. Cell evolution is driven proliferation death, as well advection diff...

To investigate changes of MMP-9 in the rat spleen and hypoxia-induced microvascular basement membrane under high altitude hypoxia. Thirty male specific pathogen-free Sprague Dawley rats were randomly divided into control hypoxia groups, with 15 each group. The group placed Dingxi City, Gansu Province (2080 m above sea level) for 30 days. Rats raised a hypoxic environment Maduo County, Qinghai (...

Background : Hypoxia inducible factor 1 alpha (HIF1A) is a master regulator of acute hypoxia; however, with chronic hypoxia, HIF1A levels return to the normoxic levels. Importantly, the genes that are involved in the cell survival and viability under chronic hypoxia are not known. Therefore, we tested the hypothesis that chronic hypoxia leads to the upregulation of a core group of genes with as...

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Various in vitro preconditioning strategies have been implemented to increase the regenerative capacity of MSCs. Among them are modulation culture atmosphere (hypoxia or anoxia), three-dimensional (3D), addition trophic factors (in form growth factors, cytokines hormones), lipopolysaccharides, and pharmacological agents. Preconditioning mesenchymal stem cells by culturing a hypoxic environment,...