We conducted online electronic searches (published manuscripts in English) of the Cochrane Library, pub med and manual searches of selected specialty journals to identify any pertinent literature. The search was conducted using the key words ‘celiac disease’, ‘gluten related disorder’, ‘non celiac gluten sensitivity’, ‘wheat allergy’, ‘gluten’, , ‘gluten free diet’. Studies not published in Eng...

BACKGROUND Gluten-free foods have increased in popularity over the past decade and are now being consumed by individuals without celiac disease. However, the physiologic effects of gluten intake in individuals without celiac disease remain unknown. High-abundance plasma proteins involved in inflammation, endothelial function, and other physiologic pathways may represent potential biomarkers of ...

Celiac disease is a life-long condition with significant morbidity and health-care costs (1). Conventional understanding of etiopathological factors, specifically the roles played by theHLAgenes (DQ2 andDQ8), has greatly advanced in recent years. Furthermore, it is nowwell accepted that these HLA genes contribute to an increased risk of celiac disease for first-degree relatives of those affecte...

CONTEXT Since the advent of serologic testing for celiac disease, most persons who receive a diagnosis of celiac disease have few or no symptoms. Although pathologic changes of celiac disease resolve on a gluten-free diet, how a gluten-free diet affects the quality of life for patients with screen-detected celiac disease is unclear. OBJECTIVE To evaluate the effect of a gluten-free diet on th...

BACKGROUND Atypical presentations of celiac disease appear to be at least as common as is the classic presentation of steatorrhea, diarrhea, and weight loss. OBJECTIVE We examined the effect of a gluten-free diet on gastrointestinal symptoms in a cohort of US patients with celiac disease. DESIGN A follow-up survey was conducted in 215 patients who were evaluated at the University of Iowa fr...

OBJECTIVE To investigate the presence of autoantibody deposition against type 2 tissue transglutaminase (TG2; a reliable marker of the whole spectrum of gluten sensitivity) in the jejunal tissue and brain of patients with gluten ataxia and in control subjects. METHODS The authors evaluated jejunal biopsy samples from nine patients with gluten ataxia and seven patients with other causes of ata...

Celiac disease is an immune-mediated inflammatory disorder of the small intestine caused by sensitivity to dietary gluten and related proteins in genetically predisposed individuals. Over the past several years, the concept of non-celiac gluten sensitivity (NCGS) has gained significant interest from the scientific community and mass media and the number of individuals embracing a gluten-free di...

celiac disease (cd) is defined as a permanent intolerance to gluten with clinical manifestations and abnormal small intestinal mucosa. a case series study was performed to obtain information about clinical manifestations, age of presentation and diagnosis of cd. for this purpose, hospital records of patients who were admitted to the gastrointestinal ward in the children's medical center fr...

OBJECTIVE A possible association of celiac disease with psychiatric and psychological disturbances such as attention-deficit/hyperactivity disorder (ADHD) has been reported repeatedly. The objective of this study was to observe whether a gluten-free diet could alleviate the behavioral symptoms in patients with celiac disease and ADHD. METHOD Sixty-seven subjects aged 7 to 42 years (mean = 11....

Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing food in subjects who are not affected by either celiac disease (CD) or wheat allergy Published online: November 26, 2015 Prof. Carlo Catassi Via F Corridoni 11 IT–60123 Ancona (Italy) E-Mail c.catassi @ univpm.it © 2015 S. Karger AG, Basel 025...