Canine distemper virus (CDV) uses signaling lymphocyte activation molecule (SLAM), expressed on immune cells, as a receptor. However, epithelial and neural cells are also affected by CDV in vivo. Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody. In dogs with distemper, CDV antigen was...

PURPOSE Cidofovir (CDV) is an U.S. Food and Drug Administration (FDA)-approved nucleoside antiviral agent used to treat severe human cytomegalovirus (HCMV) infection. Until now, no clear therapeutic effects of CDV have been reported outside of the setting of viral infection, including a potential role for CDV as an antineoplastic agent for the treatment of brain tumors. EXPERIMENTAL DESIGN We...

This study examined the phylogenetic relationship of strains of canine distemper virus (CDV) collected from Paraná State, Brazil, based on the hemagglutinin gene. Urine samples were collected from 4 dogs from northern Paraná State that demonstrated clinical manifestations of canine distemper. The participation of CDV was initially confirmed by RT-PCR targeting the nucleocapsid protein, after wh...

Canine distemper virus (CDV) is a member of the genus morbillivirus, which is known to cause a variety of disorders in dogs including demyelinating leukoencephalitis (CDV-DL). In recent years, substantial progress in understanding the pathogenetic mechanisms of CDV-DL has been made. In vivo and in vitro investigations provided new insights into its pathogenesis with special emphasis on axon-mye...

Canine distemper virus (CDV) has been postulated to play a role in multiple sclerosis (MS), primarily on the basis of epidemiological evidence that has never been confirmed. However, this anecdotal association is still made by physicians and veterinarians. Although morbilliviruses such as CDV and measles virus (MV) potentially use the same cell surface receptor, CDV and others animal morbillivi...

A notion of a Frobenius manifold with a nice real structure was introduced by Hertling. It is called CDV structure (Cecotti-Dubrovin-Vafa structure). In this paper, we introduce a “positivity condition” on CDV structures and show that any Frobenius manifold of rank two with real spectrum can be equipped with a positive CDV structure. We extend naturally the symmetries of Frobenius structures gi...

Canine distemper virus (CDV) creates a very contagious viral multi-systemic canine distemper (CD) disease that affects most species of Carnivora order. The virus is genetically heterogeneous, particularly in section of the hemagglutinin (H) gene. Sequence analysis of the H gene can be useful to investigate distinction of various lineages related to geographical distribution and CDV molecular ep...

UNLABELLED Fewer than 500 Amur tigers (Panthera tigris altaica) remain in the wild. Due to low numbers and their solitary and reclusive nature, tiger sightings across their range in the Russian Far East and China are rare; sightings of sick tigers are rarer still. Serious neurologic disease observed in several wild tigers since 2001 suggested disease emergence in this endangered species. To inv...

The conventional neuropathological manifestation of canine distemper virus (CDV) infection is characterized by demyelinating encephalomyelitis. Other recognized non-conventional neuropathological manifestations of distemper include acute encephalopathy, acute encephalitis, polioencephalomalacia, inclusion body polioencephalitis, and old dog encephalitis. With the use of molecular techniques, CD...

In order to evaluate the potential application value of cidofovir (CDV) in the prevention of human papillomavirus (HPV) infection and treatment of cervical cancer, the inhibitory effect of CDV on the proliferation of HPV 18-positive HeLa cells in cervical cancer was preliminarily investigated, using cisplatin (DDP) as a positive control. An MTT assay was used to analyze the effects of CDV and D...