Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived (MANF) are involved in neuroprotection mitigating endoplasmic reticulum (ER) stress the brain peripheral organs. In earlier work, an increase histone acetylation, following treatment with epigenetic modulator, valproic acid, was associated induction of CDNF MANF cultured cells rat brain. These findings prompted inv...

We consider the problem of minimizing expected prediction cost, when there are costs associated with determining attribute values. Given a Boolean hypothesis function and a sample of this function, we seek to minimize the average prediction cost over the sample (Sample-BFE problem). We define and explore two different versions of this problem and show how existing work can be used to yield appr...

Neuroinflammation is recognized as a major factor in Parkinson's disease (PD) pathogenesis and increasing evidence propose that microglia is the main source of inflammation contributing to the dopaminergic degeneration observed in PD. Several studies suggest that astrocytes could act as physiological regulators preventing excessive microglia responses. However, little is known regarding how ast...

Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects. Recent studies show that salidroside has neurotrophic and neuroprotective effects. However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the...

The green and one-step synthesis of gold nanoparticles (Au-NP) incorporated into electrospun cyclodextrin-nanofibers (CD-NF) without the use of a carrier polymer matrix was achieved in this study. Chemically modified CD (hydroxypropyl-b-cyclodextrin (HPbCD)) was used as both a reducing and stabilizing agent as well as a fiber matrix for the electrospinning of HPbCD/Au-NP-NF composite mats. Elec...