نتایج جستجو برای: cd44 s
تعداد نتایج: 717493 فیلتر نتایج به سال:
BACKGROUND Numerous studies examining the relationship between CD44 expression and prognostic impact in patients with osteosarcoma have yielded inconclusive results. The aim of this meta-analysis was carried out to investigate the relationship between CD44 expression and the survival in patients with osteosarcoma. METHODS We therefore conducted a meta-analysis to provide a comprehensive evalu...
In this work, novel mitochondrial and CD44 receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were proposed. The amphiphilic nanocarrier was prepared by (5-carboxypentyl)triphenylphosphonium bromide (TPP), oligomeric hyaluronic acid (oHA), disulfide bond, and curcumin (Cur), named as TPP-oHA-S-S-Cur. The TPP targeted the mi...
اندومتریوز یک بیماری مزمن است که مشخصه آن رشد بافت اندومتر در محلهای دیگری غیر از حفره ی رحمی است. cd44 یک گیرنده غشایی است که در چسبندگی و مهاجرت سلولها نقش دارد. پروتئین های غشایی اینتگرال زیادی از سطح به صورت پروتئولیتیکی توسط فرآیند ریزش اکتودومین ترشح می شوند و به این ترتیب پروتئین محلول ایجاد می شود. cd44 یکی از انبوه رسپتورهایی است که برای آنها فرآیند ریزش اکتودومین نشان داده شده است. هد...
The ERM proteins, ezrin, radixin, and moesin, are involved in the actin filament/plasma membrane interaction as cross-linkers. CD44 has been identified as one of the major membrane binding partners for ERM proteins. To examine the CD44/ERM protein interaction in vitro, we produced mouse ezrin, radixin, moesin, and the glutathione-S-transferase (GST)/CD44 cytoplasmic domain fusion protein (GST-C...
The CD44 cell surface glycoprotein is expressed on a broad range of different tissues as multiple isoforms containing from one to ten alternatively spliced exons v1-v10 inserted within the extracellular domain. Differential glycosylation generates still further variability, yielding both N- and O-glycan-modified forms of CD44 in addition to proteoglycan-like variants containing chondroitin sulp...
BACKGROUND Human prostate basal cells expressing alpha-6 integrin (CD49f(Hi)) and/or CD44 form prostaspheres in vitro. This functional trait is often correlated with stem/progenitor (S/P) activity, including the ability to self-renew and induce differentiated tubules in vivo. Antigenic profiles that distinguish tubule-initiating prostate stem cells (SCs) from progenitor cells (PCs) and mature l...
The need for antibody proteins is growing both diagnosis and therapy. In this work, we combine two strategies based on single nanopore sensing multipore membrane to separate, detect identify antibodies. This proof of concept was done the anti-CD44. a first step, with bullet shape were designed using track-etching polymer film functionalized, PEG spacer CD44 antigen. detection anti-CD44 evidence...
Stem cells may play a role in the development and maintenance of proliferative diseases of the prostate such as prostate cancer and benign prostatic hyperplasia. Cell membrane protein markers, CD49f, CD133 and CD44, have been shown to identify putative prostate stem cells, but a lack of consensus exists with regards to the most efficient marker(s) for stem-like cell identification. This study a...
BACKGROUND The biological functions of regulatory factor (RF)X1, a transcription factor, are not known. Since the RFX1 gene is often epigenetically silenced and clusters of differentiation (CD)44 proteins that regulate cancer cell biology are increased in human glioblastomas, we designed this study to determine whether RFX1 could regulate CD44 expression in glioblastoma. METHODS Regulatory fa...
Despite the widespread use of the cell-surface receptor CD44 as a marker for antigen (Ag)-experienced, effector and memory T cells, surprisingly little is known regarding its function on these cells. The best-established function of CD44 is the regulation of cell adhesion and migration. As such, the interactions of CD44, primarily with its major ligand, the extracellular matrix (ECM) component ...
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