Background: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries. CD4+ T cells are known to play a role in the progression of the disease. CD4+CD25+Foxp3+ natural Treg (nTreg) cells seem to have a protective role in the disease and their reduction in acute coronary syndrome is recently shown. Objective: To investigate the frequency of nTreg subsets in the pe...

Background:   Brucellosis is one of the most common chronic diseases, with widespread distribution. In spite of cell-mediated immunity (CMI) modulated mainly via activated T-helper type 1 (Th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. Regulatory T cells (Treg cells) are involved the immune response to brucellosis; however, their role, particularly in...

Background. We aimed to analyze the contents of main CD4+ T-cell subsets in patients with atherosclerosis (AS) depending on age. Methods. Male coronary and/or carotid AS, who are non-smokers, and receiving statins were divided into three age groups (I—<55 y.o. (n = 23), II—55–64 42), III—≥65 46)). Leukocyte phenotyping was performed by direct immunofluorescence flow cytometry. For intracellu...

Background: Ovarian cancer is the fifth leading cause of death from malignancy in women. CD4 +CD25+FoxP3+ regulatory T (Treg) cells are a subset of T lymphocytes with great inhibitory impact on immune response. Objectives: To investigate the percentage of CD4 +CD25+FoxP3+ regulatory T cells in the peripheral blood of the Iranian patients with epithelial ovarian cancer compared to healthy women ...

background:   brucellosis is one of the most common chronic diseases, with widespread distribution. in spite of cell-mediated immunity (cmi) modulated mainly via activated t-helper type 1 (th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. regulatory t cells (treg cells) are involved the immune response to brucellosis; however, their role, particularly in the chang...

objective: micrornas (mirna) are a class of non-coding rnas which play key roles in post-transcriptional gene regulation. previous studies indicate that mirnas are dysregulated in patients with multiple sclerosis (ms). th17 and regulatory t (treg) cells are two subsets of cd4+ t-cells which have critical functions in the onset and progression of ms. the current study seeks to distinguish fluctu...

behcet disease (bd) is a systemic inflammatory disease of the unknown etiology. there is however, some evidence to suggest that immunological abnormalities are important in its pathogenesis, furthermore several t-cell abnormalities which may be quite relevant to autoimmune origin of the disease have been described. we report here our study of t-cell subsets, b and nk cells in 68 patients with b...