background lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. immune dysregulation in the pathogenesis of oral lichen planus (olp) is well-known phenomenon. objectives in this study, we compared the levels of the peripheral blood t lymphocytes between patients with olp and control group. patients and methods in this study, 32 and 16 patients respect...

Blinatumomab is a bispecific anti-CD3 and anti-CD19 antibody that acts as T-cell engager: by binding CD19+ lymphoblasts, blinatumomab recruits cytotoxic CD3+ T-lymphocytes to target the cancer cells. Here we describe seven different patients affected B-cell precursor acute lymphoblastic leukemia (Bcp-ALL) treated with blinatumomab, on which evaluated potential association between amount of T-ce...

We have identified a large population of CD3(-)7(+) cells in human fetal gut. Three- and four-color flow cytometry revealed a distinct surface Ag profile on this population; the majority were negative for CD4 and CD8, whereas most of the remainder expressed the CD8alphaalpha homodimer. In contrast about half of CD3(+) cells expressed CD4 and half expressed CD8alpha. A large proportion of CD3(-)...

Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac patients with a borderline histology. Objective: To determin...

BACKGROUND The purpose of this study was to investigate Tim-3 expression on peripheral CD3-CD56+ natural killer (NK) cells and CD3+CD56+ natural killer T (NKT) cells in lung cancer patients. MATERIALS AND METHODS We analyzed Tim-3+CD3-CD56+ cells, Tim-3+CD3-CD56dim cells, Tim-3+CD3-CD56bright cells, and Tim- 3+CD3+CD56+ cells in fresh peripheral blood from 79 lung cancer cases preoperatively ...

T-cells undergo polyclonal expansion in cutaneous psoriasis (PsC) and PsA, with persistence of “driver clones” after effective treatment (JCI 127:4031; JI 172:1935). A recent scRNA-seq study found roughly equal compartments clonal non-clonal Th17 Tc17 cells PsC (Science 371:364). We others have shown that from PBMC requires contact between monocytes memory the context TCR ligation (PNAS 104:170...

It is impossible to solve the socio-economic problem of increasing birth rate in Ukraine without determining mechanisms pregnancy disorders, among which immune ones occupy an important place, and developing individualized scientifically based therapy schemes. Purpose - determine characteristics levels immunocompetent blood cells on CD phenotype women with a history infertility at different stag...

Objective(s): To investigate the systemic and local immune status of two surgical rat models of sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection Materials and Methods:Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group), sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was perfor...

Immunomagnetic beads (IMBs) for cell sorting are universally used in medical and biological fields. At present, the IMBs on market ferrite coated with a silicon shell. Based new type of magnetic material, graphene iron nitride particle (G@FeN-MP), which we previously reported, prepared novel IMB, oxide immune bead (GO@FeN-IMBs), explored its feasibility sorting. First, surface G@FeN-MP was oxid...