نتایج جستجو برای: cd3

تعداد نتایج: 11176  

Journal: :Critical Care 2009
Jorge Monserrat Raul de Pablo Eduardo Reyes David Díaz Hugo Barcenilla Manuel R Zapata Antonio De la Hera Alfredo Prieto Melchor Álvarez-Mon

INTRODUCTION Given the pivotal role of T lymphocytes in the immune system, patients with septic shock may show T cell abnormalities. We have characterised the T cell compartment in septic shock and assess its clinical implications. METHODS T lymphocytes from the peripheral blood of 52 patients with septic shock and 36 healthy control subjects were analysed on admission to the intensive care u...

Journal: :The Journal of Experimental Medicine 1992
S Koyasu L D'Adamio A R Arulanandam S Abraham L K Clayton E L Reinherz

CD3 zeta and CD3 eta form disulfide-linked homo- or heterodimers important in targeting partially assembled Ti alpha-beta/CD3 gamma delta epsilon T cell receptor (TCR) complexes to the cell surface and transducing stimulatory signals after antigen recognition. Here we identify a new TCR isoform expressed on splenic CD2+, CD3/Ti alpha-beta+, CD4-, CD8-, CD16+, NK1.1+ mouse large granular lymphoc...

Journal: :The Journal of Experimental Medicine 1997
Judith A. Smith J. Yun Tso Marcus R. Clark Michael S. Cole Jeffrey A. Bluestone

Anti-CD3 monoclonal antibodies (mAbs) are potent immunosuppressive agents used in clinical transplantation. However, the activation-related adverse side effects associated with these mAbs have prompted the development of less toxic nonmitogenic anti-CD3 mAb therapies. At present, the functional and biochemical consequences of T cell exposure to nonmitogenic anti-CD3 is unclear. In this study, w...

Journal: :Journal of immunology 2005
Ute Gunther Judith A Holloway John N Gordon Andrea Knight Victoria Chance Neil A Hanley David I Wilson Ruth French Jo Spencer Howard Steer Graham Anderson Thomas T MacDonald

We have identified a large population of CD3(-)7(+) cells in human fetal gut. Three- and four-color flow cytometry revealed a distinct surface Ag profile on this population; the majority were negative for CD4 and CD8, whereas most of the remainder expressed the CD8alphaalpha homodimer. In contrast about half of CD3(+) cells expressed CD4 and half expressed CD8alpha. A large proportion of CD3(-)...

Journal: : 2022

It is impossible to solve the socio-economic problem of increasing birth rate in Ukraine without determining mechanisms pregnancy disorders, among which immune ones occupy an important place, and developing individualized scientifically based therapy schemes. Purpose - determine characteristics levels immunocompetent blood cells on CD phenotype women with a history infertility at different stag...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Li-Yun Xu Dong-Dong Chen Jian-Ying He Chang-Chang Lu Xiao-Guang Liu Han-Bo Le Chao-Ye Wang Yong-Kui Zhang

BACKGROUND The purpose of this study was to investigate Tim-3 expression on peripheral CD3-CD56+ natural killer (NK) cells and CD3+CD56+ natural killer T (NKT) cells in lung cancer patients. MATERIALS AND METHODS We analyzed Tim-3+CD3-CD56+ cells, Tim-3+CD3-CD56dim cells, Tim-3+CD3-CD56bright cells, and Tim- 3+CD3+CD56+ cells in fresh peripheral blood from 79 lung cancer cases preoperatively ...

2006
Edgar Fernández-Malavé Ninghai Wang Manuel Pulgar Wolfgang W. A. Schamel Balbino Alarcón

Humans lacking the CD3 subunit of the pre-TCR and TCR complexes exhibit a mild T lymphopenia, but have normal T cells. By contrast, CD3 -deficient mice are almost devoid of mature T cells due to an early block of intrathymic development at the CD4 CD8 double-negative (DN) stage. This suggests that in humans but not in mice, the highly related CD3 chain replaces CD3 during T-cell development. To...

Journal: :The Journal of Experimental Medicine 1997
Johannes B. Huppa Hidde L. Ploegh

The T cell receptor for antigen (TCR) is a multisubunit complex that consists of at least seven polypeptides: the clonotypic, disulfide-linked alpha/beta heterodimer that is noncovalently associated with the invariant polypeptides of the CD3 complex (CD3-gamma, -delta, -epsilon) and zeta, a disulfide-linked homodimer. We achieved the complete assembly of the human TCR in an in vitro transcripti...

Journal: :acta medica iranica 0
a. danesh m. mir-ahmadian

peripheral blood t lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. three monoclonal antibodies (anti-cd3, anti cd-f, unti-cds) were simultaneously applied for detection of th (cd3-, cd4^), tsk (cd3+, cd8+) and th/ts ratio by flow-cytometry respectively. the results of this study sho...

Journal: :iranian journal of immunology 0
sara assadiasl department of immunology, school of medicine pedram ahmadpoor chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences mohsen nafar chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences mahboob lessan pezeshki nephrology research center, tehran university of medical sciences fateme pourrezagholi chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences mahmoud parvin department of pathology, labbafinejad hospital, shahid beheshti university of medical sciences, tehran, iran abtin shahlaee

background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...

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