Introduction: Peripheral and central nerve injuries cause chronic neuropathic pain in many injured people besides motor disability. Exercise, as a behavioral and non-pharmacological treatment, has beneficial effects on people’s general health both for healthy and sick people. Therefore, this study was conducted to examine the effects of exercise on neuropathic pain induced by chronic cons...

BACKGROUND AND THE PURPOSE OF THE STUDY Pentoxifylline (PTX) is a non-specific cytokite pain in several animal models and humans. However, long-term therapeutic effects of PTX on neuropathic pain in a rat model of chronic constriction injury (CCI) are not completely clear. This study was conducted to examine the effect of long-term administration of PTX on neuropathic pain in rats. METHODS Ne...

Neuropathic pain can arise from a lesion affecting the peripheral nervous system. Selective P2X(3) and P2X(2/3) receptors' antagonists effectively reduce neuropathic pain. VEGF inhibitors are effective for pain relief. The present study investigated the effects of Vatalanib (VEGF receptor-2 (VEGFR-2) inhibitor) on the neuropathic pain to address the interaction of VEGFR-2 and P2X(2/3) receptor ...

OBJECTIVE To investigate the effect of COX inhibitors on pain threshold and spinal N-methyl-D-aspartate (NMDA) receptor subunit 2B (NR2B) expression in a rat model of neuropathic pain. METHODS Thirty-six male SD rats were randomly divided into sham-operated group, chronic constriction injury (CCI) of the sciatic nerve group, indomethacin+CCI group, and parecoxib+CCI group with corresponding t...

In our previous study, the ethanolic and aqueous extracts of Crocus sativus elicited antinociceptive effects in the chronic constriction injury (CCI) model of neuropathic pain. In this study, we explored anti-inflammatory, anti-oxidant and anti-apoptotic effects of such extracts in CCI animals. A total of 72 animals were divided as vehicle-treated CCI rats, sham group, CCI animals treated with ...

Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitudinal and additive nature of chronic conditions. In this paper, we explore longitudinal comorbidity metrics and their value in predicting mortality....

The paper develops Child-Computer Interaction (CCI) for 86 children including 42 boys and 44 girls aged 4-6 out of four kindergartens in Taipei City, Taiwan. CCIe is an implication of embodied interaction with Kinect. CCIt is tactile interaction with iPad. CCIm is a multimodal interaction, an innovative integration of iPad and Kinect. The effectiveness of the CCI is evaluated by problemsolving ...

Multi input multi output system (MIMO) has become a viable option to meet the demand of high data rate wireless communication. But MIMO system performance is severely affected by the presence of co-channel interference (CCI). CCI cancellation in MIMO channel therefore is a challenging area of research. This paper provides a Kalman Filter based CCI cancellation approach which is connected to pha...

By applying interference-aware channel segregation based dynamic channel assignment (IACS-DCA) algorithm, each access point (AP) can use a channel with low co-channel interference (CCI) in a distributed manner. Interference environment may vary due to e.g., switching on/off of APs. Its adaptability to varying CCI environment has been left as an interesting study. In this paper, we investigate t...