The antidiarrheal effects of chloroform, methanol, and aqueous extracts of Bidens odorata Cav. were investigated at doses of 200 mg/kg on castor-oil-induced diarrhea. The chloroform extract of B. odorata (CBO) reduced diarrhea by 72.72%. The effect of CBO was evaluated on mice with diarrhea induced by castor oil, MgSO4, arachidonic acid, or prostaglandin E2. CBO inhibited the contraction induce...

An assay has been developed in which the activity of an ubiquinol oxidase from Escherichia coli, cytochrome bo(3) (cbo(3)), is determined as a function of the hydrophobic substrate ubiquinol-10 (UQ-10) in tethered bilayer lipid membranes (tBLMs). UQ-10 was added in situ, while the enzyme activity and the UQ-10 concentration in the membrane have been determined by cyclic voltammetry. Cbo(3) is i...

Objective functions in large-scale machine-learning and artificial intelligence applications often live high dimensions with strong non-convexity massive local minima. First-order methods, such as the stochastic gradient method Adam, are used to find global Recently, consensus-based optimization (CBO) has been introduced one of gradient-free methods its convergence is proven dimension-dependent...

The bug prediction effectiveness reasonably contributes towards enhancing quality of software. Bug indicators contribute significantly in determining the bug prediction approaches and help in achieving software reliability. Various comparative research studies have indicated that Depth of Inheritance (DIT), Weighted Method per Class (WMC), Coupling between Objects (CBO) and Lines of Code (LoC) ...

BACKGROUND UNAIDS has called for greater HIV/syphilis testing worldwide just as local HIV/syphilis testing programs are cut or altered. New models are needed to make HIV/syphilis testing services sustainable while retaining their essential public health function. Social entrepreneurship, using business principles to promote a social cause, provides a framework to pilot programs that sustainably...

Combinatory therapies have been commonly applied in the clinical setting to tackle multi-drug resistant bacterial infections and these have frequently proven to be effective. Specifically, combinatory therapies resulting in synergistic interactions between antibiotics and adjuvant have been the main focus due to their effectiveness, sidelining the effects of additivity, which also lowers the mi...

International donors have increasingly shifted AIDS funding directly to community-based organizations (CBOs) with the assumption that responding to the epidemic is best achieved at the community level. The World Bank, ICF Macro, and the National Council for Population and Development in Kenya, conducted a study to evaluate the community response in Kenya. The study used a quasi-experimental des...

To determine the alterations in optical characteristics and cerebral blood oxygenation (CBO) during activation and deactivation, we evaluated the changes in mean optical pathlength (MOP) and CBO induced by a verbal fluency task (VFT) and driving simulation in the right and left prefrontal cortex (PFC), employing a newly developed time-resolved near infrared spectroscopy, which allows quantitati...

Magnetic B-stars often exhibit circularly polarized radio emission thought to arise from gyrosynchrotron by energetic electrons trapped in the circumstellar magnetosphere. Recent empirical analyses show that onset and strength of observed scale with both magnetic field stellar rotation rate. This challenges existing paradigm are accelerated current sheet between opposite-polarity lines outer re...