The membrane-associated enzyme L-α-glycerol-3-phosphate oxidase (GlpO) of Mycoplasma mycoides subs. mycoides (Mmm), the causal agent of contagious bovine pleuropneumonia (CBPP) has been identified as a virulence factor responsible for the release of toxic by-products such as H2O2 that mediate host cell injury. Since CBPP pathogenesis is based on host inflammatory reactions, we have determined t...

To facilitate the evaluation of vaccines against bovine herpesvirus type 1 (BHV-1), a cotton rat model of intranasal (i.n.) BHV-1 infection was established. Cotton rat lung cells were similar to bovine cells in their ability to support BHV-1 replication in vitro. Furthermore, i.n. inoculation of cotton rats with BHV-1 resulted in pulmonary lesions comparable to BHV-1 infection in cattle. Using ...

Enterohemorrhagic Escherichia coli (EHEC) are important human pathogens, causing hemorrhagic colitis and hemolytic uraemic syndrome in humans. E. coli O157:H7 is the most common serotype associated with EHEC infections worldwide, although other non-O157 serotypes cause life-threatening infections. Cattle are a main reservoir of EHEC and intervention strategies aimed at limiting EHEC excretion f...

Tropical theileriosis or Mediterranean Coast Fever - caused by Theileria annulata - is a disease of cattle widely distributed across southern Europe, north Africa and central Asia. Its distribution broadly corresponds with that of its main ixodid tick vectors Hyalomma excavatum and H. detritum (Fig. 1). 'Exotic' cattle (Bos taurus) are particularly susceptible with mortalities up to 40-80% in s...

The tuberculin skin test is commonly used in tuberculosis (TB) eradication programmes in cattle (Monaghan et al., 1994). The detection of false-positive reactors is important particularly in areas where there is a relatively low incidence of the disease, and can be attributed, at least in part, to immunological cross-reactivity with other mycobacteria infections. Of particular concern is Mycoba...

207 Mukhebi, A.W., Morzaria, S.P., Perry, B.D., Dolan, T.T. and Norval, R.A.I., 1990. Cost analysis of immunization for East Coast fever by the infection and treatment method. Prevo Vet. Med., 9: 207219. East Coast fever is a major disease of cattle in eastern, central and southern Africa. Its control has relied on the effective control of the vector tick, Rhipicephalus appendiculatus. Recently...