The association of secreted frizzled related protein type 4 (Sfrp4) as an antagonist of Wnt mole-cules in apoptotic events has been reported previously. Moreover, its increased expression has been reported in the ovary of women with polycystic ovary (PCO). We have demonstrated in-creased Sfrp4 in PCO-induced rat ovary related to an increased number of apoptotic follicles showing nuclear ?cateni...

Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that affects cholesterol homeostasis. Recent research has found PCSK9 various effects on the heart are unrelated to LDL regulation. The Wnt/β-catenin signaling pathway plays crucial role during development, and it re-activated in response cardiac injury. Low-density lipoprotein receptor-related proteins 5 (LR...

The stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the...

The importance of dissecting signaling pathways governing cell differentiation is based on their relevance not only for understanding basic biological phenomena but also better comprehending the underlying mechanisms pathologic alterations such as cancer. A paradigm processes hematopoiesis, where a single stem gives rise to multiple, fully differentiated, lineages. Nucleoredoxin (Nrx), member t...

Hepatoprotective effect of gallic acid against type 2-induced diabetic liver injury in male rats through modulation fetuin-A and GLP-1 with involvement ERK1/2/NF-κB Wnt1/β-catenin signaling pathways

Canonical WNT/β-catenin signaling is a central pathway in embryonic development, but it is also connected to a number of cancers and developmental disorders. Here we apply a combined in-vitro and in-silico approach to investigate the spatio-temporal regulation of WNT/β-catenin signaling during the early neural differentiation process of human neural progenitors cells (hNPCs), which form a new p...

Colorectal cancer (CRC) is the third most frequent and second leading cause of cancer-related deaths globally. Evidence shows that over 90% CRC cases are initiated by a deregulated Wingless Integrated Type-1 (WNT)/β-catenin signaling pathway. The WNT/β-catenin pathway also promotes cell proliferation, stemness, metastasis. Therefore, modulators may serve as promising regimens for CRC. This stud...

Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway is an evolutionarily conserved which not only important for regulation of embryogenesis and organ development, but also injury repair, homeostasis tissue remodeling. Dysregulation this either by upregulation or even downregulation highly implicated in various diseases such as; liver diseases, kidney lung fibrosis, heart failure, va...

Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell maintenance. Reduced activation of the Wnt/β-catenin pathway underlies neurodegenerative disorders and aberrations in bone formation. Screening of a small molecule compound library with a β-galactosidase fragment complementation assay measuring β-catenin nuclear entry revealed bona fide activators of β-caten...

Dysregulation of specific microRNAs or Wnt/β-catenin signaling pathway is critically implicated in the pathogenesis of various renal diseases. However, the relationship between microRNAs and Wnt/β-catenin signaling in diabetes-induced glomerular sclerosis remains unknown. Here, we found that decreased miR-29a expression and attenuated Wnt/β-catenin signaling were concomitantly detected in glome...