It has been reported that inhibition of fatty-acid synthase (FAS) is selectively cytotoxic to human cancer cells. Considerable interest has developed in identifying novel inhibitors of this enzyme complex. Our previous work showed that green tea (-)-epigallocatechin gallate can inhibit FAS in vitro. To elucidate the structure-activity relationship of the inhibitory effects of tea polyphenols, w...

The widespread consumption of diets rich in anthocyanin and catechin content prompted the evaluation of their in vitro inhibitory effects on cyclooxygenase (COX) enzymes and on the proliferation of human cancer cell lines. Five anthocyanidins consisting of cyanidin (1), delphinidin (2), pelargonidin (3), peonidin (4), and malvidin (5) were tested for COX-1 and -2 enzyme inhibitory activities at...

Stability of tea catechins during heat processing was exarnined. Effects of pH and temperature on reaction kinetics of degradation of tea catechins were investigated. Reaction of -EC was accelerated at pH higher than 6.0, inhibited at those lewer than 5.0. A dominant reaction of --EC in slightly acidic media was isomerization. The apparent first order reaction proceeded in slightly acidic media...

Green tea catechins (TC) have anti-obesity effects on atherosclerosis-susceptible mice fed atherogenic diet, but the antioxidant effect of the catechins at these conditions is not studied. Our aim is to show that green tea catechins have a favorable effect on plasma and organs lipid peroxidation parameters. For the purpose we have fed atherosclerosis-susceptible mice HF (30 %) diet containing T...

Increasing interest in the health benefits of tea has led to the inclusion of tea extracts in dietary supplements and functional foods. However, epidemiologic evidence regarding the effects of tea consumption on cancer and cardiovascular disease risk is conflicting. While tea contains a number of bioactive chemicals, it is particularly rich in catechins, of which epigallocatechin gallate (EGCG)...

Tea contains a variety of bioactive compounds. In this study, we show that two O-methylated catechins, (-)-epigallocatechin-3-O-(3-O-methyl) gallate and (-)-epigallocatechin-3-O-(4-O-methyl) gallate, inhibit in vivo mast cell-dependent allergic reactions more potently than their nonmethylated form, (-)-epigallocatechin-3-O-gallate. Consistent with this, these O-methylated catechins inhibit IgE/...

A polypyrrole (PPY) coated capillary and several commercially available capillaries (capillary GC columns) were used to evaluate their extraction efficiencies for catechins and caffeine. Compared with commercial capillaries that were currently used for in-tube solid phase microextraction (SPME), the PPY coated capillary showed better extraction efficiency for all of the compounds studied. Elect...

Bioavailability of catechinsin wider range plants was established earlier and it’s utility as medicine against cardiovascular disease, cancer, etc. were also demonstrated. Recent techniques in relation to quantitative analysis total catechins seem be laborious time consuming process handle huge number samples. Established spectrophotometry HPLC methods developed for determination tea extracts c...

Much attention has been paid to the beneficial health effect of tea catechins as one of the effective strategies to prevent obesity. The current study was carried out to investigate the role of tea catechins on the utilization of dietary energy sources in rats. The addition of 1% (w/w) tea catechins, mostly in gallate forms, to the diet brought about significant reductions in body weight gains ...

Here we have investigated the inhibitory properties of green tea catechins on the Plasmodium falciparum hexose transporter (PfHT), the Babesia bovis hexose transporter 1 (BboHT1) and the mammalian facilitative glucose transporters, GLUT1 and GLUT5, expressed in Xenopus laevis oocytes. (-)-Epicatechin-gallate (ECG) and (-)-epigallocatechin-gallate (EGCG) inhibited D-glucose transport by GLUT1 an...