Glucokinase (GK), a glucose sensor, maintains plasma glucose homeostasis via phosphorylation of glucose and is a potential therapeutic target for treating maturity-onset diabetes of the young (MODY) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). To characterize the catalytic mechanism of glucose phosphorylation by GK, we combined molecular modeling, molecular dynamics (MD) simu...

In this paper, catalytic oxidation of CO over the LaFe1-xCuxO3 (x= 0, 0.2, 0.4, 0.6) perovskite-type oxides was investigated. The catalysts were synthesized by sol-gel method and characterized by XRD, BET, FT-IR, H2-TPR and SEM methods. The catalytic activity of catalysts was tested in catalytic oxidation of CO. XRD patterns confirmed the synthesized perovskites to be single-phase perovskite-ty...

a multi-objective optimization procedure has been developed to determine some kinetic parameters of free radical polymerization of vinyl acetate based on genetic algorithm. for this purpose, mathematical modeling of free radical polymerization of vinyl acetate is carried out first and then selected kinetic parameters are optimized by minimizing objective functions defined from comparing experim...

A polarographic catalytic hydrogen wave of bovine serum albumin (BSA) at about –1.80 V (vs. SCE) in NH4Cl-NH3 H2O buffer is further catalyzed by such oxidants as iodate, persulfate and hydrogen peroxide, producing a kinetic wave. Studies show that the kinetic wave is a parallel catalytic wave of hydrogen, which resulted from that hydrogen ion is electrochemically reduced and chemically regenera...

Purpose – The purpose of this paper is to propose a conceptual structural equation model to investigate the relationships among self-directed learning (SDL), organizational learning (OL), knowledge management capability (KMC) and organizational performance (OP) and to demonstrate the direct and indirect effect of SDL on OP from the perspectives of KMC and OL. Design/methodology/approach – An em...

Biphasic hydroformylation of 1-octene was performed using rhodium sulfoxantphos catalyst dissolved in [BuPy][BF4] ionic liquid. Preliminary experiments proved this system to retain the catalytic complex within the ionic liquid phase and to maintain a high selectivity towards the linear aldehyde (n:iso ratio of 30) over several cycles. Process parameter investigation showed a first order depende...

Catalytic aldolase antibodies generated by immunization with two different, but structurally related, beta-diketone haptens were cloned and sequenced to study similarities and differences between independently evolved catalysts. Kinetic and sequence analysis coupled with mutagenesis, structural, and modeling studies reveal that the defining event in the evolution of these catalysts was a somati...