Abstract The mechanism by which the combination of fluorine and aluminum (FA) cause learning memory impairment is still unclear. Curcumin a yellow polyphenol extracted from rhizome plant curcuma longa linn, has anti-apoptotic antioxidant functions; studies have shown that PKC-NMDAR pathway plays an important role in process cell apoptosis. Based on above, we designed vitro study curcumin apopto...

The adoption of new treatment modalities remains crucial as lung cancer has one the lowest survival rates, along with liver and pancreatic cancer. Bortezomib is a proteasome inhibitor that higher anticancer effect in combination therapies. Therefore, aim this study to investigate whether bortezomib could have additional when combined cyclin-dependent kinase (CDK) inhibitor-roscovitine vitro. Ap...

The P38 mitogen-activated protein kinase (MAPK) signal transduction pathway is widespread in organisms and plays important roles immune activities. infection mechanism of environmental gram-negative bacteria on crustaceans an scientific problem. In this study, the cDNA full-length sequence Portunus trituberculatus (PtP38) was cloned its structure analyzed by bioinformatics methods. To study fun...

conclusions it seems that the preventive effects of rutin against damages caused by ida can be attributed to its ability to reduce apoptosis, which may be mediated by underexpression of caspase3 and overexpression of bcl2 genes. also, it could increase the expression of dazl that may be important in spermatogenesis. methods in the current experimental study, balb/c mice were divided into 8 grou...

AIMS Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but whether this transcription factor acts as a signalling molecule in PGE(2)-in...

Purpose: To investigate the effect of Pinellia polysaccharide on airway remodeling in cough-variant asthmatic rats, and involvement PI3K/AKT signal route process.
 Methods: Seventy-five Sprague-Dawley (SD) rats were assigned to 5 groups: blank control, model, low-dose (100 mg/kg), medium-dose (200 mg/kg) high-dose (400 groups, each with 15 rats. Immunoblot assay was employed measure relati...

Isoflurane can provide both neuroprotection and neurotoxicity in various culture models and in rodent developing brains. Emulsified Isoflurane (EI) is an emulsion formulation of isoflurane, while its underlying molecular mechanism of developemental nerve toxicity largely remains unclear. We hypothesized that EI induced fetal neural stem cells (FNSCs) apoptosis, endoplasmic reticulum (ER) stress...

High-altitude retinopathy represents retinal functional changes associated with environmental challenges imposed by hypobaric hypoxia, but the detailed cellular and molecular mechanism underlying this process remains unclear. Our current investigation was to explore the effect of hypobaric hypoxia on the rat retina and determine whether resveratrol has a protective efficacy on the hypoxic damag...