tranexamic acid is generally used in the treatment of disorders that predispose one to bleeding. it is a synthetic lysine analog that has strong antifibrinolytic activity. plasminogen binds to fibrin to form plasmin, which in turn degrades fibrin into fibrin degradation products. tranexamic acid blocks the lysine binding site on plasminogen and prevents interaction with fibrin. tranexamic acid ...

conclusions this case highlights the potential severity of h1n1 infections and the utility of considering cardiac tamponade in patients presenting with influenza symptoms and circulatory collapse. case presentation we describe a case of a young female with no prior cardiovascular history who presents with a pericardial effusion and shock secondary to cardiac tamponade from pericarditis due to h...

introduction induction of general anesthesia in patients with superior vena cava (svc) syndrome may cause airway obstruction and cardiovascular collapse. case presentation herein, we introduced a patient with the diagnosis of dissecting aneurysm of the ascending aorta who was candidate for emergency surgery. he also had symptoms of svc syndrome. to maintain airway patency during anesthetic mana...

Cyclosporin A (CSA) suppresses immune function by blocking the cyclophilin A and calcineurin/NFAT signaling pathways. In addition to immunosuppression, CSA has also been shown to have a wide range of effects in the cardiovascular system including disruption of heart valve development, smooth muscle cell proliferation, and angiogenesis inhibition. Circumstantial evidence has suggested that CSA m...

We report a case of a 45-year-old female undergoing an emergency ventriculoperitoneal shunt surgery. The patient had brain metastatic lesions of breast carcinoma with associated hydrocephalus. She had received Adriamycin as a part of chemotherapy regimen for breast cancer. Her preoperative cardiovascular status was normal. Under general anesthesia, the patient had a sudden cardiovascular collap...