Hypertension and hypercholesterolemia frequently coexist and may require concomitant drug treatments. The efficacy and safety profile of lovastatin given in the presence of antihypertensive medication was evaluated using patient subgroups identified in the Expanded Clinical Evaluation of Lovastatin (EXCEL) Study. The EXCEL study examined 8,245 patients with moderate hypercholesterolemia randoml...

A trial natriuretic factor (ANF), a 28-amino acid peptide hormone synthesized and secreted from atrial myocytes, has been suggested to play an important role in the regulation of extracellular fluid volume and arterial pressure. Physiological and pharmacological doses of this peptide have been shown to produce natriuresis and diuresis, vasorelaxation, and inhibition or antagonism or both of imp...

Due to the aging of the populations of developed countries and a common occurrence of risk factors, it is increasingly probable that a patient may have both cancer and cardiovascular disease. In addition, cytotoxic agents and targeted therapies used to treat cancer, including classic chemotherapeutic agents, monoclonal antibodies that target tyrosine kinase receptors, small molecule tyrosine ki...

Sulfonylureas (SUs) are widely prescribed in the treatment of type 2 diabetes. Despite availability several newer agents, SUs still play an important role glucose-lowering therapy. However, over last decade, there is a degrowth older agents (SUs and thiazolidinediones) prescriptions with emergence such as dipeptidyl peptidase-4 inhibitors, sodium glucose cotransporter-2 inhibitors glucagon-like...

WHAT IS KNOWN AND OBJECTIVE Obesity affects approximately one-third of the American population, and its prevalence continues to increase. It is a significant risk factor for cardiovascular diseases and contributes to increased healthcare costs and mortality. The objective is to review the current literature on the cardiovascular effects of weight loss pharmacotherapy agents. METHODS Literatur...

The Risk Estimation of Cardiovascular Disease (CVD) is an important factor for predicting the incidence cardiovascular events in a given population. This study aimed to assess knowledge, awareness, and attitude pharmacists Jordan regarding risk estimation CVD use lipid-lowering agents. particularly interested investigating extent which are immersed this area practice, can significantly impact p...