Background—Current studies have demonstrated that applying therapeutic hypothermia for 12 to 24 hours after resuscitation from cardiac arrest improves the outcomes of cardiopulmonary resuscitation. The present study investigated whether a shorter duration of therapeutic hypothermia induced quickly and early after resuscitation would provide an equal improvement in the outcomes of cardiopulmonar...

Cardiopulmonary arrest (CPA) is characterized by abrupt, complete failure of the respiratory and circulatory systems. The lack of cardiac output and oxygen delivery to tissues (DO2) can quickly cause unconsciousness and systemic cellular death from oxygen starvation. If left untreated, cerebral hypoxia results in complete biologic brain death within 4 to 6 minutes of CPA.1,2 Therefore, prompt c...

OBJECTIVE To investigate the effects of epinephrine when administered during either normothermic or therapeutic hypothermic cardiopulmonary resuscitation on postresuscitation myocardial and cerebral function and survival. DESIGN Prospective, randomized, placebo-controlled experimental study. SETTING University-affiliated animal research laboratory. SUBJECTS Thirty-two healthy male Sprague...

OBJECTIVE A major hurdle limiting the ability to improve the quality of resuscitation has been the lack of a noninvasive real-time detection system capable of monitoring the quality of cerebral and other organ perfusion, as well as oxygen delivery during cardiopulmonary resuscitation. Here, we report on a novel system of cerebral perfusion targeted resuscitation. DESIGN An observational study...

Adrenaline (epinephrine) has been used for cardiopulmonary resuscitation since 1896; the rationale behind its use is thought to be its α-adrenoceptor-mediated peripheral vasoconstriction, causing residual blood-flow to be diverted to coronary and cerebral circulations. This protects these tissues from ischaemic damage and increases the likelihood of restoration of spontaneous circulation. Clini...

Objective: To investigate the effect of intravascular heat exchange in saving the lives of patients after cardiopulmonary resuscitation. Methods: The clinical data of a female patient who was given cardiopulmonary resuscitation for 1.67 h in July 2014 in our hospital was retrospectively analyzed. An intravascular heat exchange procedure was performed on the patient to control her body temperatu...

BACKGROUND AND PURPOSE Cerebral blood flow during cardiopulmonary resuscitation is inadequate to meet cerebral metabolic demand. Adrenergic agonists improve cerebral blood flow, but clinical trials of increased doses in adults have not shown improved outcome from cardiac arrest. This may be due to adverse beta-agonist-mediated effects. The purpose of this study was to determine the effect of an...

INTRODUCTION Hypothermia improves survival and neurological recovery after cardiac arrest. Pro-inflammatory cytokines have been implicated in focal cerebral ischemia/reperfusion injury. It is unknown whether cardiac arrest also triggers the release of cerebral inflammatory molecules, and whether therapeutic hypothermia alters this inflammatory response. This study sought to examine whether hypo...

www.ccmjournal.org 243 Objective: To determine whether implementation of Composite Resuscitation Team Training is associated with improvement in survival to discharge and code team performance after pediatric in-hospital cardiopulmonary arrest. Design, Setting, and Subjects: We conducted a prospective observational study with historical controls at a 302-bed, quaternary care, academic children’...