Thymosin-β4 (Tβ4) promotes cell survival, angiogenesis, and tissue regeneration and reduces inflammation. Cardiac rupture after myocardial infarction (MI) is mainly the consequence of excessive regional inflammation, whereas cardiac dysfunction after MI results from a massive cardiomyocyte loss and cardiac fibrosis. It is possible that Tβ4 reduces the incidence of cardiac rupture post-MI via an...

BACKGROUND Blunt traumatic cardiac rupture is rare. However, such cardiac ruptures carry a high mortality rate. This study reviews our experience treating blunt traumatic cardiac rupture. METHODS This retrospective study included 21 patients who experienced blunt traumatic cardiac rupture from 1999 to 2015. Every patient underwent surgery. Several variables were compared between survivors and...

To test the hypothesis that the electrocardiogram of cardiac rupture is due to acute cardiac tamponade, 27 episodes of cardiac tamponade were produced in ten open-chest dogs. During continuous monitoring of the electrocardiogram and the arterial and venous pressures, 10-30 cc of autologous, heparinized blood, or one of several other solutions, were intermittently infused into the pericardial sa...

To test the hypothesis that the electrocardiogram of cardiac rupture is due to acute cardiac tamponade, 27 episodes of cardiac tamponade were produced in ten open-chest dogs. During continuous monitoring of the electrocardiogram and the arterial and venous pressures, 10-30 cc of autologous, heparinized blood, or one of several other solutions, were intermittently infused into the pericardial sa...

BACKGROUND Plaque rupture may be present in the peripheral arteries of the patients at high risk for cardiovascular events and is possibly associated with vascular vulnerability. METHODS AND RESULTS One hundred one iliofemoral arteries from 101 patients undergoing angioplasty were studied. Intravascular ultrasound imaging was performed before intervention. Plaque rupture was defined as presen...

OBJECTIVES The aim of this study was to identify factors causing rupture recurrence after surgical repair of postinfarction ventricular septal rupture and to evaluate the indication for reoperation. PATIENTS Recurrence of rupture was analysed in 25 out of a series of 109 patients who underwent surgical repair for postinfarction ventricular septal rupture between 1980 and 1992 in our instituti...

Left ventricular free wall rupture and acute ischaemic mitral regurgitation are nowadays rare, but still potentially lethal mechanical complications after acute myocardial infarction. We report a case of a sequential left ventricular free wall rupture, anterolateral papillary muscle disruption, secondary severe mitral regurgitation and subsequent posteromedial papillary muscle head rupture in a...

Pathological data are given of 4 patients in whom the development of cardiac rupture was the initial sign of myocardial infarction. The term 'concealed cardiac rupture' is proposed for this condition. In each instance the clinical diagnosis was 'onset of infarction', whereas the necropsy suggested that the acute onset of symptoms was caused by the start of rupture. The arguments for classifying...

A sinus of Valsalva aneurysm (SOVA) is an uncommon cardiac anomaly occurring in less than 1% of patients undergoing open cardiac surgical procedures (1). Approximately 65-85% of SOVAs originate from the right sinus of Valsalva, while SOVAs originating from noncoronary (10-30%) and left sinuses (<5%) are less common (2). It may be congenital or acquired in origin and may rupture into any of the ...