In rats exposed to a single intraperitoneal dose of 200 mg/kg of the environmental carcinogen benzo[a]pyrene (BP) in sunflower oil, significant individual variations in excretion of the BP activation (BP-7,8-diol) and deactivation (3-OH-BP) derivatives were found. Most rats developed peritoneal sarcomas. Only the levels of BP-7,8-diol excreted in the urine correlated directly with the latency o...

Methylating agents are widely distributed environmental carcinogens. Moreover, they are being used in cancer chemotherapy. The primary target of methylating agents is DNA, and therefore, DNA repair is the first-line barrier in defense against their toxic and carcinogenic effects. Methylating agents induce in the DNA O(6)-methylguanine (O(6)MeG) and methylations of the ring nitrogens of purines....

MATline is a tool that can be used to predict which industrial processes can be expected to involve the use of a substance that is considered carcinogenic as documented in the literature. The database includes agents carrying risk phrases R45, R49 and R40 according to the method of classification adopted by the EU and/or agents in categories 1, 2A and 2B as classified by the International Agenc...

Alkylating agents are known to produce second tumors in cancer patients treated for their primary cancer. Since therapeutic doses are high and the pharmacokinetics of the drugs are thoroughly studied, these agents provide a unique opportunity to compare intrinsic carcinogenic potency between experimental animals and humans. We have examined the carcinogenicity of melphalan, chlorambucil, and cy...

INTRODUCTION This paper describes the available exposure information for carcinogens in Great Britain and discusses some of the issues involved in using such data to inform an assessment of the attributable occupational cancer burden. METHODS Carcinogenic agents or occupations/industries such as hairdressers were identified from the list of International Agency for Research on Cancer groups 1...

Cancer is a fatal hereditary illness produced by an unexpected alteration in genes that has the destructive potential to degrade healthy human cells individual. This disease distinguished uncommon molecular promotes unregulated cell proliferation body, which can quickly spread other sites body. Several variables cause cancer humans; these factors might be biological or environmental. Cancer-cau...

Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens that includes a number of environmentally important /V-nitrosocompounds. A number of alkylating agents are also useful antitumor drugs. There are many factors determining the sensitivity to the toxic, mutagenic, and carcinogenic poten tial of these compounds (1-4).2 O...

background: radon and its short-lived decay products are considered as the important sources of public exposure to natural radioactivity. the synergistic interaction between tobacco smoking and radon is known to be an actual problem. this study has provided a mathematical description and prognosis of the carcinogenic effects after combined action of radon with smoking. materials and methods: a ...