A large variety of environmental carcinogens are metabolically activated to electrophilic metabolites that can bind to nucleic acids and protein, forming covalent adducts. The formation of DNA-carcinogen adducts is thought to be a necessary step in the action of most carcinogens. Recently, a variety of new fluorescence, immunochemical, and radioactive-postlabeling procedures have been developed...

Arsenic is one of the most hazardous pollutants found in aqueous environments and has been shown to be a carcinogen. Phytochelatins (PCs), which are cysteine-rich and thio-reactive peptides, have high binding affinities for various metals including arsenic. Previously, we demonstrated that genetically engineered Saccharomyces cerevisiae strains expressing phytochelatin synthase (AtPCS) produced...

Hexavalent chromium Cr (VI) used in shielded metal arc welding is widely recognized to act as a carcinogen, mutagen and teratogen. The carcinogenic potential of metals is a major issue in defining human health risk from exposure. Hence in the present investigation, 66 welders and 60 control subjects with similar mean ages, smoking prevalences and alcohol consumption were enrolled for DNA damage...

Arsenic is a well-known toxic chemical and listed as a known carcinogen by the Environmental Protection Agency (EPA) and the World Health Organization (WHO, 2001). It is the 20 abundant element in the earth s crust but is widely distributed in the environment being released from both natural sources, e.g. by volcanic action, during weathering of rocks and mining as well as from anthropogenic on...

textile effluents contain different kinds of chemical dyes and many mutagenic and carcinogenic substances. discharge of these effluents into terrestrial and aquatic ecosystems causes harmful effects. in this research, decolorization of a textile effluent by nineteen different strains of fungi was investigated. removal activity of dyes was in order of   aspergillus > rhizopus > fuzarium > penici...

This review evaluates the epidemiological literature on health effects in relation to incineration facilities. Several adverse health effects have been reported. Significant exposure-disease associations are reported by two thirds of the papers focusing on cancer (lung and larynx cancer, non-Hodgkin's lymphoma). Positive associations were found for congenital malformations and residence near in...

Hexavalent chromium is highly toxic to most living organisms and a known human carcinogen by the inhalation route of exposure. Therefore, treatment of Cr(VI) contaminated wastewater is essential before their discharge to the natural water bodies. Cr(VI) reduction to Cr(III) can be beneficial because a more mobile and more toxic chromium species is converted to a less mobile and less toxic form....