BACKGROUND AND PURPOSE Carbon monoxide produces relaxation in some peripheral arteries. Recently it has been suggested that carbon monoxide may be generated in brain tissue. In the present study we examined the hypothesis that carbon monoxide directly relaxes cerebral blood vessels. METHODS The aorta and basilar and middle cerebral arteries were removed from New Zealand White rabbits and moun...

The authors declare we have no actual or potential competing financial interests. Abbreviations: Author's contributions to the study: LWT, KFH and ITY defined the research theme. LWT, KFH, WT, HQ and VCP analyzed the data, interpreted the results and wrote the paper. JCC and PKL co-worked on associated data collection and their interpretation. Abstract Recent experimental and clinical studies s...

INTRODUCTION Carbon monoxide poisoning is a very common cause of death in accidental, suicidal, or homicidal cases throughout the world. Fingernail bed manifestation is reported in survivors of carbon monoxide poisoning. CASE PRESENTATION A 40-year-old Caucasian woman was exposed to carbon monoxide when she was sleeping alone in her one-bedroom apartment; fortunately, the beeps from her First...

Background Carbon monoxide is the leading cause of mortality from unintentional poisoning in Slovenia. It has been shown that carbon monoxide levels can rise in wood pellet storerooms because of chemical degradation of pellets, even at room temperature. We present a case of lethal carbon monoxide poisoning with first responder carbon monoxide exposure. Aims To highlight the dangers rescuers f...

BACKGROUND Cardiopulmonary bypass (CPB) is associated with pulmonary inflammation and dysfunction. This may lead to acute lung injury and acute respiratory distress syndrome with increased morbidity and mortality. The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs. METHODS In a porcine model, a beating-heart CPB was u...

BACKGROUND Cardiopulmonary bypass (CPB) may cause acute lung injury leading to increased morbidity and mortality after cardiac surgery. Preconditioning by inhaled carbon monoxide reduces pulmonary inflammation during CPB. We hypothesized that inhaled carbon monoxide mediates its anti-inflammatory and cytoprotective effects during CPB via induction of pulmonary heat shock proteins (Hsps). METH...

Carbon monoxide poisoning is common and carries significant morbidity and mortality. The nervous system, particularly the brain, is frequently affected by it, owing to its high metabolic activity and oxygen requirements. Carbon monoxide damages the nervous system by both hypoxic and inflammatory mechanisms. Central diabetes insipidus is an extremely rare complication of carbon monoxide poisonin...

the objective of this study was to simulate carbon monoxide (co) dispersion exited from the stacks of a cement industry in doroud, iran by gaussian model (gm). four sampling period was conducted for the measurement of co from the factory's three-stack flow during a period of one year. the input parameters were the rate of co emission, meteorological data,  factors related to the stack, and...

Septic cardiac dysfunction is the main cause of death in septic patients. Here we investigate whether exogenous carbon monoxide can protect cardiac function and improve survival against sepsis by interfering with mitochondrial energetic metabolism. Male C57BL/6 mice were subjected to cecal ligation and puncture to induce sepsis. Exogenous carbon monoxide delivered from Tricarbonyldichlororuthen...

OBJECTIVES To investigate the acute cardiovascular effects of smoking shisha. DESIGN A cross-sectional study was carried out in six shisha cafes. Participants smoked shisha for a period between 45 min (minimum) and 90 min (maximum). The same brand of tobacco and coal was used. SETTING London, UK. PARTICIPANTS Participants were those who had ordered a shisha to smoke and consented to have ...