Introduction: Carbapenem resistance in Gram-negative bacilli (GNB) is a major concern the management of resistant infections. The mechanism carbapenem most commonly mediated by carbapenemases. five common genes (NDM, KPC, VIM, OXA, and IMP) are responsible for carbapenemase production. Knowledge these important disease. Objective: To estimate prevalence different production GNB at tertiary heal...

b ackground : one of the main mechanisms of resistance to carbapenems is potential of klebsiella pneumoniae to produce k . pneumoniae carbapenemase (kpc). kpc is an important type of carbapenemase, which can hydrolyze carbapenems and other beta-lactam antibiotics. modified hodge test (mht) and  use  of  boronic  acid  as  a  kpc  inhibitor  are  two  types  of  phenotypic methods, which are use...

Many hospital antimicrobial stewardship programs restrict the availability of selected drugs by requiring prior approval. Carbapenems may be among the restricted drugs, but it is unclear if hospitals that restrict availability actually use fewer carbapenems than hospitals that do not restrict use. Nor is it clear if restriction is related to resistance. We evaluated the relationship between car...

BACKGROUND Carbapenem-resistance is rapidly evolving among the pathogenic microbes in intensive care units (ICUs). This study aimed to determine annual trend of carbapenem-resistance in the ICU for 4 years, since the opening of a university-affiliated hospital in South Korea. METHODS From 2005 to 2008, microbial samples from consecutive 6,772 patients were screened in the ICU. Three hundred a...

BACKGROUND Colistin-resistant/carbapenem-resistant Acinetobacter baumannii is a significant challenge for antibiotic treatment and infection control policies. Since 2012, in Central Greece an increase of colistin/pan- resistant A. baumannii has occurred, indicating the need for further analysis. METHODS A total of 86 colistin-resistant/carbapenem-resistant out of 1228 A. baumannii clinical is...

AIM To evaluate the diagnostic performance of MDI and temocillin disk (30 μg) for detection of carbapenem-resistant Enterobacteriaceae in comparison to real-time PCR. MATERIAL AND METHODS Fifty specimens submitted to the Microbiology Laboratory of Ain Shams University Hospitals and showed resistance to carbapenem drugs through routine culture and susceptibility testing, were assessed by both ...

BACKGROUND National surveillance of antimicrobial resistance becomes more important for the control of antimicrobial resistance and determination of treatment guidelines. We analyzed Korean Antimicrobial Resistance Monitoring System (KARMS) data collected from 2013 to 2015. METHODS Of the KARMS participants, 16 secondary or tertiary hospitals consecutively reported antimicrobial resistance ra...

INTRODUCTION Bacterial resistance is a growing concern in the nosocomial environment in which Klebsiella pneumoniae and Enterobacter aerogenes play an important role due to their opportunism and carbapenemase-production. This work aimed to evaluate physiological and molecular characteristics of carbapenem-resistant K. pneumoniae and E. aerogenes isolated in a Brazilian tertiary hospital. METH...

The emergence of resistance to multiple antimicrobial agents in pathogenic bacteria is a significant public health threat, as there are limited effective antimicrobial agents for infections caused by multidrug-resistant (MDR) bacteria. Several MDR bacteria are now frequently detected. Carbapenem resistance in Enterobacteriaceae is often plasmid mediated, necessitating stringent infection contro...

objectives the objective of this study was to develop the primers for single and/or multiplex pcr amplification assays for simultaneous identification of class a, class b, and class d carbapenem hydrolyzing β-lactamases in enterobacteriaceae and then to evaluate their efficiency. conclusions we have reported here a reliable method, composed of single and multiplex pcr assays, for screening all ...