Both stem cells and cancer cells are thought to be capable of unlimited proliferation. Moreover, a small number of cancer cells express stem cell markers, including CD133 and ATP-binding cassette transporters, by which the cells can pump out specific fluorescence dyes, such as Hoechst33342, as well as anti-cancer drugs, suggesting that either cancer cells resemble stem cells or cancers contain ...

Aim: The low-density lipoprotein receptor gene (LDLR) family plays a fundamental role in many malignancies and may have putative cancer-boosting function. In our study, we attempted to comparatively investigate the differential expressions of LDLR normal prostate epithelial cell line (RWPE-1), cancer (DU145 line), stem cells CSCs) non-CSCs non-CSCs, bulk population). 
 Materials Methods: C...

Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of normal stem cell thus contributing towards aggressiveness cancer by playing crucial role in tumor recurrence metastasis capability. Various studies have been conducted to therapeutically target CSCs. One the approaches include is inhibit cycle progression last two decades various components its regulation firmly ...

Cancer stem cells (CSCs) are believed to cause cancer metastasis and recurrence. BEX2 (brain expressed X-linked gene 2) is a CSC-related that in dormant CSCs cholangiocarcinoma induces resistance against chemotherapy. The aim of the present study was identify small compounds have activity inhibit expression result attenuation phenotypes. We screened 9600 chemical high-throughput screening using...

Background and Aim: Cancer stem cells (CSCs) have been proposed as a driving force of tumor initiation, dissemination drug resistance. The protease inhibitor SerpinB3 (SB3) has involved in the early events hepatocarcinogenesis, is highly expressed hepatic progenitor cells. However, only limited information on possible role SB3 cholangiocarcinoma (CCA) stem-like compartment available.

Colorectal Cancer (CRC) is the second most common cancer in women and third men. There strong evidence for role of Stem Cells (CSCs) progression. The identification understanding CSCs genes such as LGR5 involved induction development crucial prognosis CRC. a membrane protein several molecular signaling pathways, Wnt NOTCH pathways. It has been shown that gene was overexpressed CRC associated wi...

Lung cancer is one of the most common cancers in world and a leading cause death. Cancer stem cells (CSCs) are responsible for tumor initiation. CSCs features include self-renewal capacity, differentiation, high invasion-migration, resistance to chemotherapy. characterized by specific surface markers. CD133 widely used as marker many cancers, including lung cancer. CD133-positive an important b...

Malignant gliomas are highly invasive brain tumors with the occurrence of multiple microglia/macrophages in the tumor microenvironment. Macrophages/microglia that found in glioma microenvironment, as tumor-infiltrating immune cells, can play a harmful role in tumor progression. In addition, glioblastoma multiforme (GBM) contains multiple aberrant differentiation and tumorigenic cancer stem cell...

Cancer stem cells (CSCs) are the in a primary tumor that have opportunity to self-renew as well differentiate into certain cell types, thus forming mixed tumor. CSCs been shown be involved every aspect of cancer development, including initiation, proliferation, and metastatic activity; they also chemotherapeutic drug resistance recurrence cancers. Based on these capabilities, explored next targ...