Aspartoacylase (ASPA)-deficient patients [Canavan disease (CD)] reportedly have increased urinary excretion of N-acetylaspartylglutamate (NAAG), a neuropeptide abundant in the brain. Whether elevated excretion of urinary NAAG is due to ASPA deficiency, resulting in an abnormal level of brain NAAG, is examined using ASPA-deficient mouse brain. The level of NAAG in the knockout mouse brain was si...

TumourMarkers-Dr. A. R. Lyons. Improvement ofDiagnostic Precision of Treadmill Exercise Testing by Analysis of Blood Pressure Changes During Recovery-Drs. P. Morton, G. Murtagh, M. E. Scott, and Dr. K. Balnave by invitation. Animalcules-Dr. D. A. Canavan. Cushing's Syndrome-Professor D. A. D. Montgomery. A P. P. oma Syndrome-Professor K. D. Buchanan. Emergency Geriatric MedicalAdmissions-Profes...

The primary purpose of this work was to assess long-term in vitro reproducibility of metabolite levels measured using 1H MRS (proton magnetic resonance spectroscopy). The secondary purpose was to use the in vitro results for interpretation of 1H MRS in vivo spectra acquired from patients diagnosed with Canavan disease. 1H MRS measurements were performed in the period from April 2006 to Septembe...

In [BH5] it is shown how the Relative Hurewicz Theorem follows from a Generalised Van Kampen Theorem (GVKT) for the fundamental crossed complex of a filtered space, and in [BL3] it is shown how a new multirelative Hurewicz Theorem follows from a GVKT for the fundamental cat-group of an n-cube of spaces. The purpose of this paper is to advertise and explain some implications and special cases of...

Introduction Over the past decade, performance-based grants (PBGs) have emerged as a new set of interventions in which specific actions are requested, received and paid for. They reward results with payment, aiming principally to resolve issues of access, utilization and provider performance (Meesen et al., 2006; Canavan, Toonen & Elovainio 2008). Defined here as “the provision of incentives to...

Heterogeneous duopolies with product differentiation and isoelastic price functions are examined in which one firm is quantity setter and the other is price setter. The reaction functions and the CournotBertrand (CB) equilibrium are first determined. It is shown that the best response dynamics with continuous time scales and without time delays is always locally asymptotically stable. This stab...

We investigate the influence of additive Gaussian white noise on two different bistable self-sustained oscillators: Duffing-Van der Pol oscillator with hard excitation and a model of a synthetic genetic oscillator. In the deterministic case, both oscillators are characterized with a coexistence of a stable limit cycle and a stable equilibrium state. We find that under the influence of noise, th...