Actin nucleation triggers the formation of new actin filaments and has the power to shape cells but requires tight control in order to bring about proper morphologies. The regulation of the members of the novel class of WASP Homology 2 (WH2) domain-based actin nucleators, however, thus far has largely remained elusive. Our study reveals signal cascades and mechanisms regulating Cordon-Bleu (Cob...

Algorithms for shape offsetting are of great importance in computer-aided design (CAD), computer-aided manufacturing (CAM), the numerical control (NC) of machines, computer graphics and related fields. The need for offset shapes arises in applications such as the numerical control of sawing machines or milling machines in the car industry. The problem of shape offsetting can be formulated as fo...

PURPOSE To retrospectively characterize magnetic resonance (MR) arthrographic findings in patients with cam femoroacetabular impingement (FAI) and in those with pincer FAI. MATERIALS AND METHODS Institutional review board approval and informed consent were not required. MR arthrographic studies obtained in 50 consecutive patients (30 men, 20 women; mean age, 28.8 years) with FAI were analyzed...

Calcineurin (CaN) is a Ca2+/calmodulin-dependent Ser/Thr protein phosphatase, which plays essential roles in many cellular and developmental processes. CaN comprises two subunits, a catalytic subunit (CaN-A, 60 kDa) and a regulatory subunit (CaN-B, 19 kDa). CaN-A tightly binds to CaN-B in the presence of minimal levels of Ca2+, but the enzyme is inactive until activated by CaM. Upon binding to ...

OBJECTIVE Statistical shape modelling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort. METHOD SSM was perfo...

This paper presents an online tool that offers designers, artists and all creative people, the possibility of exploring and accessing Europeana in a funny, playful and intuitive way. By using the webcam to take a photo of any object or texture, users can invoke the Culture Cam tool for accessing a set of images that are similar in color, shape or pattern. It is used to stimulate the inspiration...

AIM Implant rehabilitation of the atrophic right posterior mandible in a 48-year-old woman using dehydrated homologous bone block, shaped with a computer aided design-computer aided manufacturing (CAD-CAM) system, to avoid harvesting of autologous bone block and to assure a perfect fitting of the block above the alveolar crest. RESULTS After 7 months, 6.09, 7.36, and 8.08 mm (mean, 7.18 mm) o...

INTRODUCTION: Improper resection depth in the surgical correction of cam-type femoroacetabular impingement (FAI) has been identified as the most common reason for revision hip arthroscopy [1]. Under-resection fails to address patient symptoms and results in the need for revision arthroscopy [1], while over-resection may lead to iatrogenic femoral neck fracture, loss of the normal joint suction ...

1. Abstract 2. Introduction 3. Techniques Used for Measuring Binding Affinity 4. Organization of the Erythrocyte Membrane Skeleton 4.1. Maintenance of Erythrocyte Shape 4.2. Maintenance of Erythrocyte Membrane Mechanical Properties 5. 4.1R as a Modulator in a Complex Membrane System 5.1. Facilitation of p55 Binding to GPC 5.2. Modulation of Ankyrin Binding to Transmembrane Proteins 5.3. Facilit...

A dumbbell-type (DT) protein comprises two globular domains and one helical segment connecting these globular domains. DT protein plays an important role in the regulation of other proteins. Calmodulin (CaM), a typical DT protein, for example, is a soluble calcium-binding protein that regulates several enzymes such as smooth muscle, myosin light-chain kinase and Ca2+/CaM-dependent protein kinas...