نتایج جستجو برای: caloric restriction igf 1 learning
تعداد نتایج: 3340349 فیلتر نتایج به سال:
in this study, the effects of late gestational undernutrition (lgu) on plasma concentration of insulin-like growth factor 1 (igf-i), leptin, insulin and glucose in subsequent sucking lambs was investigated. ten twin-bearing ewes were fed either restrictedly (restricted) or adequately (control) during the last six weeks of gestation and were fed ad libitum after parturition. blood samples were t...
OBJECTIVE Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function models for the GOAT/ghrelin/growth hormone secretagogue receptor (GHSR) system, we thoroughly tested the hypothesis that lack-of-ghrelin activation or ...
The inhibitory effect of caloric restriction on the formation of tumors in the mouse has been shown (1 I) to be dependent on the actual degree of caloric restriction. Previously it had been demonstrated (8) that restriction of caloric intake to about 60 per cent of the ad libitum intake causes an inhibition in tumor formation regardless of whether only the carbohydrate component is restricted (...
We investigated the role of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis on caloric restriction (CR) using male wild-type and transgenic homozygous dwarf rats bearing an antisense GH transgene and their F1 heterozygous progeny fed either ad libitum or subjected to 30% CR. CR predominantly altered expression of hepatic genes involved in the stress response, xenobiotic metaboli...
The inhibitory effect of caloric restriction on the formation of tumors in the mouse has been shown (1 I) to be dependent on the actual degree of caloric restriction. Previously it had been demonstrated (8) that restriction of caloric intake to about 60 per cent of the ad libitum intake causes an inhibition in tumor formation regardless of whether only the carbohydrate component is restricted (...
A considerable amount of evidence is consistent with the proposition that systemic IGF-I activity acts as pacesetter in the aging process. A reduction in IGF-I activity is the common characteristic of rodents whose maximal lifespan has been increased by a wide range of genetic or dietary measures, including caloric restriction. The lifespans of breeds of dogs and strains of rats tend to be inve...
conclusions aed improved liver enzymes in obese women. however, mild, transient increases in alt and ast values can be observed immediately after an nfd in women. results of 108 participants, 50 women in aed group and 50 women in nfd group completed the protocol of the study (response rate: 92.6 %). the aed led to a median weight loss of 3.79 kg (interquartile range: 4.4 kg). significant decrea...
Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...
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