1. Sodium phosphate was infused intravenously over approximately 2+ h and produced a mean linear rise in plasma phosphorus levels of 9.1 mg/100 ml. Twentyone infusions were performed in twelve control subjects and thirty-eight were carried out in thirty-two patients with disorders of calcium and phosphorus metabolism. 2. The fall in plasma calcium under these conditions was related to: a. The i...

Problem statement: There is evidence that the type of fiber influences the development of nephrocalcinosis in rats, but the effect of pectin was unknown. Approach: The effects of dietary pectin and cellulose on kidney calcification were studied in female rats. The diets used contained either 0.4-0.6% phosphorus and either cellulose (10%, w/w) or pectin. The purified diets used were balanced for...

BACKGROUND Calcium is an essential cotherapy in osteoporosis treatment. The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance. OBJECTIVE Our objective was to test the hypothesis that calcium phosphate would better support anabolic bone building than would calciu...

Hyperphosphatemia and secondary hyperparathyroidism are common complications of ESRD (chronic kidney disease stage 5) that, when untreated, may result in increased morbidity and mortality. Hyperphosphatemia and hypercalcemia have been associated with increased coronary artery calcification. Achieving control of serum phosphorus without increasing serum calcium is an important goal for patients ...

background: zinc is an essential trace element required for the functional activity of several enzyme systems. several studies have been carried out to assess the effect of zinc supplementation on children’s growth, but controversy exists as to the effect of zinc on growth and gh-igf-i system. objective:  the aim of this study was to evaluate the effect of zinc supplementation on linear growth ...

BACKGROUND Patients with secondary hyperparathyroidism often require therapy that provides long-term control of parathyroid hormone concentrations without increasing calcium and phosphorus concentrations. Cinacalcet modulates the calcium-sensing receptor on the parathyroid gland to reduce secretion of parathyroid hormone and lower serum calcium, phosphorus and calcium-phosphorus product in haem...

The extracellular calcium regulation of parathyroid hormone (PTH) secretion is mediated by a cell surface G-protein-coupled calcium receptor (PCaR). The abnormal calcium sensing in renal failure could be the result of abnormalities of the PCaR. However, PCaR gene expression has been shown to be unaffected by 5/6 nephrectomy in the rat. Whether factors that enhance secondary hyperparathyroidism ...

A HIGH incidence of phosphate urinary calculi in sheep has been associated with the feeding of rations containing dibasic potassium phosphate (Lindley et al., 1953; Elam et al., 1956, 1957). Further, Lindley et al. (1953) observed elevated plasma phosphorus levels under these conditions. Emerick et al. (1959) observed high plasma phosphorus levels in lambs subsequently afflicted with urinary mi...

BACKGROUND Abnormalities in serum phosphorus, calcium and parathyroid hormone (PTH) have been associated with poor survival in haemodialysis patients. This COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) analysis assesses the association of high and low serum phosphorus, calcium and PTH with a relative risk of mortality. Furthermore, the impact of...

Phosphorus intake in Europe is far above recommendations. We present baseline data from three human intervention studies between 2006 and 2014 regarding intake and excretion of phosphorus and calcium. All subjects documented their nutritional habits in weighed dietary records. Fasting blood samples were drawn, and feces and urine were quantitatively collected. Dietary phosphorus intake was esti...