Many Helicobacterpylori strains causing gastroduodenal diseases have a cagA gene encoding CagA protein, a virulence factor of these bacteria. Anti-CagA antibodies produced by the majority of people infected with CagA(+) strains can indicate such an infection. In this study, the efficacy of three immunoenzymatic tests for detecting CagA(+) and CagA(-) infections were compared: immunoblot (Mileni...

INTRODUCTION: Costa Rica has among the highest mortality rates from gastric cancer in world, largely due to late detection. It is therefore important that economically and logistically sustainable screening implemented order detect risk of developing cancer. We have previously shown low pepsinogen (PG) values infection with Helicobacter pylori-CagA+ are associated atrophy Rican populations. OBJ...

The human gastric lumen is one of the most hostile environments of the human body suspected to be sterile until the discovery of Helicobacter pylori (H.p.). State of the art next generation sequencing technologies multiply the knowledge on H.p. functional genomics as well as on the colonization of supposed sterile human environments like the gastric habitat. Here we studied in a prospective, mu...

background: to asses the status of two representative genes of cag pai i.e caga and cage of helicobacter pylori strains infecting iranian patients suffered from various clinical outcomes using one-step pcr. methods: a total of 120 h. pylori infected patients including non-ulcer dyspepsia, nud (n=81), peptic ulcer disease, pud (n=17), and gastric carcinoma, gc (n= 22) referred for endoscopy or g...

Approximately 60% of Helicobacter pylori isolates in the Western world possess the cytotoxin-associated gene A (cagA). cagA-positive H. pylori is found to be associated with peptic ulcer disease (PUD) and gastric adenocarcinoma. To investigate the cagA status of H. pylori isolates from Chinese patients with PUD and chronic gastritis (CG), H. pylori populations from 83 patients, 48 with PUD and ...

Considering that the role of Helicobacter pylori infection in gastroesophageal reflux and reflux esophagitis (GERD) is still controversial and that the role of virulence markers of the bacterium has not been evaluated in most studies of GERD, we investigated the association among H. pylori infection with cagA-positive and -negative strains, corpus gastritis, and GERD in a large group of patient...

OBJECTIVES Helicobacter pylori infection occurs worldwide, but the prevalence of this infection varies greatly among different countries and population groups. The aim of this study was to determine the seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A (CagA) antibodies in asymptomatic healthy population in the center of Iran and to investigate the relation with di...

The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, ...

PURPOSE Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of H. pylori by type of chronic gastritis; (ii) to describe the frequency of cagA, babA2 and vacA genotypes...

background and objective: helicobacter pylori has several strains with different degrees of virulence. the aim of this study was to detect two major important virulence factors, caga/vaca genotypes, and to determine correlations among different caga/vaca genotypes and histological features of chronic gastritis in iranian patients. methods: in this cross- sectional study, gastric biopsy was take...