Trichosanthin (TCS) is a type I ribosome-inactivating protein (RIP) possessing N-glycosidase activity. TCS has various pharmacological properties, including immunomodulatory, anti-tumor and anti-HIV activities. Up to seven C-terminal residues of TCS (TCS-C7) can be deleted resulting in lower antigenicity with minimal effects on its activity. However, an additional problem is that the minimal ef...

BACKGROUND Persons with low back pain fail to show the same transition as healthy individuals from in-phase to anti-phase rotation of the thorax and pelvis as walking speed increases. The purpose of this study was to determine if the relative phase of the thorax and pelvis during walking was a reliable (within day test-retest) and valid measure for persons with thoracic pain. METHODS The time...

ABSTRACT Objectives: Evaluate the surgical treatment of scoliotic curvature effects and sagittal radiographic parameters spine upper limbs after with direct vertebral rotation (DVR) associated type 1 osteotomy in adolescents idiopathic scoliosis (AIS). Material Methods: 41 patients AIS were evaluated compared before surgery. Scoliosis was confirmed by a spine. The were: Cobb angles (proximal di...

Study Design Retrospective radiographic study. Objective To investigate changes and correlations of cervical sagittal alignment including T1 slope before and after occipitocervical corrective surgery. We also investigated the relevance for preoperative planning. Methods We conducted a retrospective radiographic analysis of 27 patients who underwent surgery for occipitocervical deformity. There ...

ABSTRACT Objective: To analyze the cervical sagittal parameters of patients with rheumatoid arthritis (RA) and compare them obtained from healthy in a sample Brazilian population. Methods: Epidemiological data were collected 72 radiographs spine plane evaluated by measuring COG-C7 (distance measured between center gravity head C7 plumb line -cranial offset), C2-C7 lordosis (vertebrae C2 to C7),...

The inflammatory form of epidermolysis bullosa acquisita is caused by autoantibodies against type VII collagen (C7), a component of the dermal-epidermal junction. We have previously shown that myeloid Src family kinases mediate skin inflammation triggered by anti-C7 antibodies. Here we identify the Syk tyrosine kinase as a critical component of autoantibody-induced skin inflammation downstream ...

The Chang 7 member of the Upper Triassic Yanchang Formation in Ordos Basin is considered to hold main source rocks for conventional and unconventional oil gas. lamination or lithology alteration vertical lateral directions, even over a short distance, common feature lacustrine rocks. differences geochemical characteristics black shales, dark mudstones interbedded sandstones have been scarcely r...

Toward the mavacurane and akuammilane monoterpene indole alkaloids, we developed divergent oxidative couplings between nucleus (at N1 or C7) C16-malonate of a common tricyclic model related to strictosidine according biosynthetic hypothesis postulated by Hesse Schmid. These cyclizations led selectively formation N1–C16 bond pleiocarpamine C7–C16 strictamine. We were then able obtain scaffold ta...