PURPOSE ZD6126 is a novel vascular targeting agent currently undergoing clinical evaluation. It acts by destabilizing the microtubulin of fragile and proliferating neoendothelial cells in tumors. The drug leads to blood vessel congestion, the selective destruction of the vasculature, and extensive necrosis in experimental tumors. The aim of the study reported here was to assess the ability of d...

Using harmonized micro data, this paper investigates the job search methods of the unemployed in Europe. The analysis focuses on the importance of individual and household characteristics in this context, as well as on cross-country diff erences in Europe. Our fi ndings suggest that both individual and household characteristics play an important role, with the latter being more decisive for wom...

The use of aggregate scores on item response assessments as a proxy for an underlying trait in an econometric model generally produces biased estimators. I show that if the number of items on the assessment is proportional to the square root of the sample size then standard inferential procedures for the linear regression model are incorrect. I propose a bias-corrected estimator based on nonpar...

We present a general method that allows to estimate the low-energy constants of Chiral Perturbation Theory up to next-to-leading corrections in the 1/NC expansion, that is, keeping full control of the renormalization scale dependence. As a first step we have determined L8 and C38, the couplings related to the difference of the two-point correlation functions of two scalar and pseudoscalar curre...

The sensitivity of coccolithophores to changing CO2 and its role modulating cellular photosynthetic carbon isotopic fractionation (εp) is crucial understand the future adaptation these organisms higher world assess reliability εp for past estimation. Here, we present measured on natural fossil samples across glacial-interglacial (G-I) variations marine isotope stages 12 9 interval (454–334 ka) ...

Earlier kinetics studies on cytoglobin did not assign functional properties to specific structural forms. Here, we used defined monomeric and dimeric forms and cysteine mutants to show that an intramolecular disulfide bond (C38-C83) alters the dissociation rate constant of the intrinsic histidine (H81) (∼1000 fold), thus controlling binding of extrinsic ligands. Through time-resolved spectra we...

Using harmonized micro data, this paper investigates the job search methods of the unemployed in Europe. The analysis focuses on the importance of individual and household characteristics in this context, as well as on cross-country diff erences in Europe. Our fi ndings suggest that both individual and household characteristics play an important role, with the latter being more decisive for wom...