OBJECTIVE To study the effect of cytokines on the transactivation of the c-fos gene in relation to the contribution of overexpression of c-fos/AP-1 in rheumatoid joint destruction. METHODS The promoter region (-447 to +109) of the human c-fos gene was integrated upstream of the chloramphenicol acetyltransferase (CAT) reporter gene, and the effect of cytokines on the expression of the c-fos ge...

Although the c-Fos leucine zipper (LZ) does not form a homodimer in its native basic region/leucine zipper (bZIP) structure, we found that it is capable of homodimerization and promoting protein folding in engineered basic region/helix-loop-helix/leucine zipper (bHLHZ) hybrid proteins MaxbHLH-Fos and ArntbHLH-Fos, in which the bHLH subdomains of Max and Arnt are fused to the c-Fos LZ. By using ...

The inducible transcriptional complex AP-1, composed of c-Fos and c-Jun proteins, is crucial for cell adaptation to many environmental changes. While its mechanisms of activation have been extensively studied, how its activity is restrained is poorly understood. We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that ...

slope stability analysis is an enduring research topic in the engineering and academic sectors. accurate prediction of the factor of safety (fos) of slopes, their stability, and their performance is not an easy task. in this work, the adaptive neuro-fuzzy inference system (anfis) was utilized to build an estimation model for the prediction of fos. three anfis models were implemented including g...

For years, the biochemical processes that are triggered by harmful and non-harmful stimuli at central nervous system level have been extensively studied scientific community through numerous techniques animal models. example, one of these is use immediate expression genes, which a useful, accessible, reliable method for observing quantifying cell activation. It has shown both c-fos gene its pro...

The proto-oncogene c-fos was transiently upregulated in primitive hematopoietic stem (Lin-Sca-1(+)) cells stimulated with stem cell factor, interleukin-3 (IL-3), and IL-6. To investigate a role of the c-fos in hematopoietic stem cells, we used bone marrow (BM) cells from transgenic mice carrying the c-fos gene under the control of the interferon-alpha/beta-inducible Mx-promoter (Mx-c-fos), and ...

Slope stability analysis is an enduring research topic in the engineering and academic sectors. Accurate prediction of the factor of safety (FOS) of slopes, their stability, and their performance is not an easy task. In this work, the adaptive neuro-fuzzy inference system (ANFIS) was utilized to build an estimation model for the prediction of FOS. Three ANFIS models were implemented including g...

an immediate early response gene involved in cell proliferation and differentiation after extracellular stimuli, whereas its deregulation has been associated to oncogenic progression. As other members of the FOS family proteins (Fra-1, Fra-2, FosB) and proteins of the ATF family, c-Fos can heterodimerize with members of the JUN family (c-Jun, JunB, JunD) to form the transcription factor activat...