Candida albicans accumulates large amounts of the polyols glycerol and d-arabitol when the cells are exposed to physiological conditions relevant to stress and virulence in animals. Intracellular concentrations of glycerol are determined by rates of glycerol production and catabolism and of glycerol uptake and efflux through the plasma membrane. We and others have studied glycerol production in...

Candida albicans is an opportunistic pathogen, which primarily affects neonates and immunocompromised individuals. The pathogen can invade the central nervous system, resulting in meningitis. At present, the pathogenesis of C. albicans meningitis is unclear. We used an in vitro model of the human blood-brain barrier to investigate the interaction(s) of C. albicans with human brain microvascular...

background: candida albicans (c. albicans) may have cariogenic potential but its role in caries etiology has not been established. the aim of this study was to determine c. albicans in supragingival dental plaque and infected dentine of cervical and proximal in early childhood caries (ecc). methods: this cross-sectional study was carried out on 6o children aged 2-5 years, which were divided int...

the growing number of immunocompromised individuals has increased the incidence of infections caused by candida species during the recent decades. typing of c. albicans on the basis of dna sequences at multiple loci has greatly advanced our knowledge about the epidemiology and phylogeny of candidiasis. the aim of this study was to evaluate the diversity, and genetic relationships among c. albic...

Although Candida dubliniensis is a close genetic relative of Candida albicans, it colonizes and infects fewer sites. Nearly all instances of candidiasis caused by C. dubliniensis are restricted to the oral cavity. As cell surface hydrophobicity (CSH) influences virulence of C. albicans, CSH properties of C. dubliniensis were investigated and compared to C. albicans. Growth temperature is one fa...

Prokaryote-eukaryote interactions are ubiquitous and have important medical and environmental significance. Despite this, a paucity of data exists on the mechanisms and pathogenic consequences of bacterial-fungal encounters within a living host. We used the nematode Caenorhabditis elegans as a substitute host to study the interactions between two ecologically related and clinically troublesome ...

Antibiotic-treated and untreated Syrian hamsters were inoculated intragastrically with Candida albicans to determine whether C. albicans could opportunistically colonize the gastrointestinal tract and disseminate to visceral organs. Antibiotic treatment decreased the total population levels of the indigenous bacterial flora and predisposed hamsters to gastrointestinal overgrowth and subsequent ...

The fungal pathogen Candida albicans is an opportunistic fungal pathogen that causes oral and vaginal mucosal infections as well as systemic disease. The ability of C. albicans to adhere to host surfaces is positively correlated with its pathogenicity. We prepared a polyclonal anti-Candida albicans antibody in chicken egg yolk (anti-C. albicans IgY) and investigated its in vitro effectiveness i...

We previously observed that gut colonization by Candida albicans promoted serum antibody response to orally administered ovalbumin in mice. We therefore postulated that C. albicans affects oral tolerance induction. The present study tested this idea. BALB/c mice were intragastrically administered with either C. albicans (1 × 10(7)) or vehicle, and the colonization was confirmed by weekly fecal ...

background: iranian (lahijan) black tea caffeine has been previously shown to have antifungal activity against candida albicans. the aim of this study was to investigate whether the combination of caffeine and fluconazole (flu) has an effective antifungal activity on a flu-resistant (mic >64mgl-1) c. albicans ptcc5027. materials and methods: caffeine from lahijan black tea was extracted and its...