Understanding mechanisms by which glibenclamide stimulates insulin release is important, particularly given recent promising treatment by glibenclamide of permanent neonatal diabetic subjects. Antidiabetic sulfonylureas are thought to stimulate insulin secretion solely by inhibiting their high-affinity ATP-sensitive potassium (K(ATP)) channel receptors at the plasma membrane of beta-cells. This...

Collateral channels inside the human lungs? This phenomenon, first described by KOHN [1] in 1893, is the subject of recent investigations in the field of endoscopic lung volume reduction (ELVR) for the treatment of severe chronic obstructive pulmonary disease (COPD). ELVR with valves is a new and promising therapeutic option for irreversibly damaged emphysematous lungs. The aim of the therapy i...

Understanding mechanisms by which glibenclamide stimulates insulin release is important particularly given recent promising treatment by glibenclamide of permanent neonatal diabetic subjects. Anti-diabetic sulfonylureas are thought to stimulate insulin secretion solely by inhibiting their high affinity KATP channel receptors at the plasma membrane of β cells. This normally occurs during glucose...

Background: Coronary artery bypass surgery is one of the surgeries in which high blood transfusions are needed. About 20% of all surgical operations require a blood transfusion. Packed cell administration increases perioperative morbidity and mortality. In the United States, from every 1000 people, one has undergone a coronary artery bypass graft surgery, and it is estimated that around 800,000...

Abstract Turbidity currents commonly bypass sediment in submarine channels on the continental slope, and deposit lobes farther down-dip flat unconfined abyssal plain. Seafloor outcrop data have shown that transition from to deposition usually occurs over complex zones referred as channel–lobe (CLTZs). Recognition of these cores remains challenging due a lack characteristic sedimentary facies st...

Saphenous vein graft (SVG) failure secondary to degeneration can cause significant problems after coronary artery bypass surgery (CABG). Repeat revascularization by percutaneous coronary intervention can be performed after SVG failure but is often associated with less favourable clinical outcome. Treatment for chronic total occlusion (CTO) of native vessels after SVG failure among patients with...

BACKGROUND Activation of the kinase cascade (protein kinase C (PKC), tyrosine kinase (TK), and mitogen-activated protein kinase (MAPK) is a key feature of the transduction pathway, elicited by preconditioning signals and mediating their cardioprotective effects. We assessed whether such an activation occurred during cardiac operations and could thus represent a target for cardioprotective strat...