Dietary constituents of 2 types have been shown to affect the metabolism of chemical carcinogens by the microsomal mixed-function oxidase system. Naturally occurring inducers of increased activity of this system are present in plants. Cruciferous vegetables including Brussels sprouts, cabbage, and cauliflower are relatively potent in this regard. From these vegetables, three indoles with induci...

In an attempt to establish an in vitro short-term test to detect tumorpromoting agents, we studied the effects of these agents on Junctional intercellular communication in cultured Chinese hamster V79 cells using a microinjection-dye transfer technique. When Lucifer Yellow CH solu tion is injected into a cell, the average number of cells that become fluorescent after 10 min is 11.6 ±7.8 (SD). ...

A synthesis of 2-((4-phenyl-5-(2-(p-tolylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)-N’-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-yl)sulfanyl]acetohydrazide and acetophenone is reported. The title compound has been tested to possess 1.5-fold higher antioxidant ability than the control, butylated hydroxytoluene, as determi...