Cognitive deficits in brain tumors are generally thought to be relatively mild and non-specific, although recent evidence challenges this notion. One possibility is that cognitive screening tools are being used to assess cognitive functions but their sensitivity to detect cognitive impairment may be limited. For improved sensitivity to recognize mild and/or focal cognitive deficits in brain tum...

Association between signaling proteins and their cellular targets is generally thought to be highly specific (implicating a high association constant, K(a)) and, at the same time, transient or short-lived (corresponding to a high dissociation rate constant, k(d)). However, a combination of high K(a) and high k(d) would lead to a high association rate constant (k(a) = K(a)k(d)), which poses a pr...

The genetic code of the complete genomes of Plasmodium falciparum, the most lethal of the several malaria parasites, and its major African carrier, the mosquito Anopheles gambiae, were published in Nature and Science this October, bringing these tiny organisms into the same exalted domain as the human genome itself. Already it turns out that 550 of P. falciparum's 5300 genes are closely related...